UniProt O60260
E3 ubiquitin-protein ligase parkin (O60260)
E3 ubiquitin-protein ligase parkin (UniProt O60260), EC 2.3.2.-, 2.3.2.31: 34 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 68 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O60260
- Protein
- E3 ubiquitin-protein ligase parkin
- EC
- 2.3.2.-, 2.3.2.31, 6.3.2.-, 6.3.2.19
- Experimental structures
- 34
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 68 · 11 records with a druggable one
Structures
35 records of O60260 in the MolNFT archive: 34 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1IYF | Solution structure of ubiquitin-like domain of human parkin | solution nmr | A | — | — |
| 1IYF | Solution structure of ubiquitin-like domain of human parkin | solution nmr | A | — | — |
| 2JMO | IBR domain of Human Parkin | solution nmr | A | — | — |
| 2JMO | Ibr domain of human parkin | solution nmr | A | — | — |
| 4BM9 | Structure of the autoinhibited Parkin catalytic domain | x-ray diffraction | A | — | — |
| 4BM9 | Structure of the autoinhibited parkin catalytic domain | x-ray diffraction | A | — | — |
| 4I1F | Structure of Parkin-S223P E3 ligase | x-ray diffraction | A | — | — |
| 4I1F | Structure of parkin-S223P E3 ligase | x-ray diffraction | A | — | — |
| 4I1H | Structure of Parkin E3 ligase | x-ray diffraction | A | — | — |
| 4I1H | Structure of parkin E3 ligase | x-ray diffraction | A | — | — |
| 5C1Z | Parkin (UBLR0RBR) | x-ray diffraction | A, B | — | — |
| 5C23 | Parkin (S65DUblR0RBR) | x-ray diffraction | A, B | ZN, SO4, CL | 14 (best 0.67) |
| 5C23 | Parkin (S65DUBLR0RBR) | x-ray diffraction | A, B | — | — |
| 5C9V | Structure of human Parkin G319A | x-ray diffraction | A | ZN, SO4 | 3 (best 0.44) |
| 5C9V | Structure of human parkin G319A | x-ray diffraction | A | — | — |
| 5N2W | WT-Parkin and pUB complex | x-ray diffraction | A | ZN, CL, TMO | — |
| 5N2W | Wt-parkin and pub complex | x-ray diffraction | A | 3CN, ZN, CL, TMO | — |
| 5N38 | S65DParkin and pUB complex | x-ray diffraction | A | CL, ZN | 5 (best 0.73) |
| 5N38 | S65DPARKIN and pub complex | x-ray diffraction | A | 3CN, CL, ZN | — |
| 5TR5 | Solution structure of Serine 65 phosphorylated UBL domain from parkin | solution nmr | A | — | — |
| 5TR5 | Solution structure of serine 65 phosphorylated ubl domain from parkin | solution nmr | A | — | — |
| 6GLC | Structure of phospho-Parkin bound to phospho-ubiquitin | x-ray diffraction | A | ZN | — |
| 6GLC | Structure of phospho-parkin bound to phospho-ubiquitin | x-ray diffraction | A | 3CN, ZN | — |
| 6HUE | ParkinS65N | x-ray diffraction | A, B | ZN, SO4, CL | — |
| 6HUE | PARKINS65N | x-ray diffraction | A, B | ZN, SO4, CL | — |
| 6N13 | UbcH7-Ub Complex with R0RBR Parkin and phosphoubiquitin | solution nmr | B | ZN | 9 (best 0.75) |
| 6N13 | UBCH7-ub complex with R0RBR parkin and phosphoubiquitin | solution nmr | B | ZN | — |
| 8IK6 | pUbl depleted Parkin complex with pUbiquitin | x-ray diffraction | C, A | ZN, SO4 | 5 (best 0.75) |
| 8IKM | Trans complex of phospho parkin | x-ray diffraction | A, C | ZN | 3 (best 0.71) |
| 8IKT | Ternary trans-complex of phospho-parkin with cis ACT and pUb | x-ray diffraction | A, C | ZN, 3CN | 2 (best 0.73) |
| 8IKV | pUbl depleted phospho-Parkin(K211N,R163D) in complex with pUb | x-ray diffraction | C, A | ZN | 7 (best 0.67) |
| 8JWV | Untethered R0RBR | x-ray diffraction | A | ZN | 2 (best 0.54) |
| 8WZN | ParkinK211N in complex with phospho NEDD8 | x-ray diffraction | A | ZN | 4 (best 0.61) |
| 8WZO | Parkin in complex with phospho NEDD8 | x-ray diffraction | A | ZN | 4 (best 0.66) |
| O60260 | AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase parkin (O60260) | predicted | A | — | 10 (best 0.62) |
Ligands
Experiment against prediction
- 5C23 chain A against the predicted model O60260: TM-score 0.99, RMSD 0.83 Å
- 5C23 chain A against the predicted model O60260: TM-score 0.99, RMSD 0.83 Å
- 6HUE chain B against the predicted model O60260: TM-score 0.99, RMSD 0.83 Å
- 6HUE chain B against the predicted model O60260: TM-score 0.99, RMSD 0.83 Å
- 6HUE chain A against the predicted model O60260: TM-score 0.99, RMSD 0.83 Å
- 6HUE chain A against the predicted model O60260: TM-score 0.99, RMSD 0.83 Å
- 5C1Z chain A against the predicted model O60260: TM-score 0.99, RMSD 0.92 Å
- 8IK6 chain A against the predicted model O60260: TM-score 0.96, RMSD 1.51 Å
- 8IKM chain C against the predicted model O60260: TM-score 0.95, RMSD 0.84 Å
- 8IKT chain C against the predicted model O60260: TM-score 0.95, RMSD 0.84 Å
Elsewhere
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