UniProt O60244
Mediator of RNA polymerase II transcription subunit 14 (O60244)
Mediator of RNA polymerase II transcription subunit 14 (UniProt O60244): 9 experimental structures and 1 predicted model on GenesisL1, 15 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O60244
- Protein
- Mediator of RNA polymerase II transcription subunit 14
- Experimental structures
- 9
- Predicted models
- 1
- Pockets
- 15 · 3 records with a druggable one
Structures
10 records of O60244 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7EMF | Human Mediator (deletion of MED1-IDR) in a Tail-extended conformation | electron microscopy | N | — | 9 (best 0.80) |
| 7EMF | Human mediator (deletion of MED1-idr) in a tail-extended conformation | electron microscopy | N | — | — |
| 7ENA | TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED) | electron microscopy | n | — | — |
| 7ENC | TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED) | electron microscopy | n | — | — |
| 7ENJ | Human mediator (deletion of MED1-idr) in a tail-bent conformation (med-B) | electron microscopy | N | — | — |
| 7NVR | Human Mediator with RNA Polymerase II Pre-initiation complex | electron microscopy | l | — | — |
| 7NVR | Human mediator with RNA polymerase II pre-initiation complex | electron microscopy | l | — | — |
| 8GXQ | PIC-Mediator in complex with +1 nucleosome (T40N) in MH-binding state | electron microscopy | n | — | 1 (best 0.83) |
| 8TQW | Structure of human transcriptional Mediator complex | electron microscopy | N | — | 5 (best 0.88) |
| O60244 | AlphaFold monomer V2.0 prediction for mediator of RNA polymerase II transcription subunit 14… | predicted | A | — | — |
Experiment against prediction
- 7ENJ chain N against the predicted model O60244: TM-score 0.53, RMSD 4.13 Å
- 7EMF chain N against the predicted model O60244: TM-score 0.53, RMSD 4.13 Å
- 7EMF chain N against the predicted model O60244: TM-score 0.53, RMSD 4.13 Å
- 8GXQ chain n against the predicted model O60244: TM-score 0.52, RMSD 4.25 Å
- 8TQW chain N against the predicted model O60244: TM-score 0.50, RMSD 4.71 Å
- 7ENA chain n against the predicted model O60244: TM-score 0.49, RMSD 4.95 Å
- 7ENC chain n against the predicted model O60244: TM-score 0.49, RMSD 4.97 Å
- 7NVR chain l against the predicted model O60244: TM-score 0.45, RMSD 5.28 Å
- 7NVR chain l against the predicted model O60244: TM-score 0.45, RMSD 5.28 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.