UniProt O60231
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (O60231)
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (UniProt O60231), EC 3.6.4.13: 12 experimental structures and 1 predicted model on GenesisL1, 11 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O60231
- Protein
- Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16
- EC
- 3.6.4.13
- Experimental structures
- 12
- Predicted models
- 1
- Pockets
- 11 · 8 records with a druggable one
Structures
13 records of O60231 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5Z56 | cryo-EM structure of a human activated spliceosome (mature Bact) at 5.1 angstrom. | electron microscopy | x | — | 1 (best 0.83) |
| 5Z58 | Cryo-EM structure of a human activated spliceosome (early Bact) at 4.9 angstrom. | electron microscopy | x | — | 1 (best 0.84) |
| 5Z58 | Cryo-EM structure of a human activated spliceosome (early bact) at 4.9 ångström. | electron microscopy | x | — | — |
| 6FF7 | human Bact spliceosome core structure | electron microscopy | q | — | — |
| 6FF7 | Human bact spliceosome core structure | electron microscopy | q | — | — |
| 7DVQ | Cryo-EM Structure of the Activated Human Minor Spliceosome (minor Bact Complex) | electron microscopy | x | — | 1 (best 0.84) |
| 7DVQ | Cryo-EM structure of the activated human minor spliceosome (minor bact complex) | electron microscopy | x | — | — |
| 7QTT | Structural organization of a late activated human spliceosome (Baqr, core region) | electron microscopy | N | — | 2 (best 0.89) |
| 8CH6 | Structure of a late-stage activated spliceosome (BAqr) arrested with a dominant-negative Aquarius… | electron microscopy | N | — | 1 (best 0.82) |
| 8I0T | The cryo-EM structure of human Bact-III complex | electron microscopy | X | — | 1 (best 0.88) |
| 8I0U | The cryo-EM structure of human Bact-IV complex | electron microscopy | X | — | 2 (best 0.89) |
| 8I0V | The cryo-EM structure of human post-Bact complex | electron microscopy | X | — | 2 (best 0.89) |
| O60231 | AlphaFold monomer V2.0 prediction for pre-mRNA-splicing factor ATP- dependent RNA helicase DHX16… | predicted | A | — | — |
Experiment against prediction
- 5Z58 chain x against the predicted model O60231: TM-score 0.95, RMSD 2.02 Å
- 5Z58 chain x against the predicted model O60231: TM-score 0.95, RMSD 2.02 Å
- 5Z56 chain x against the predicted model O60231: TM-score 0.95, RMSD 2.03 Å
- 6FF7 chain q against the predicted model O60231: TM-score 0.94, RMSD 2.43 Å
- 6FF7 chain q against the predicted model O60231: TM-score 0.94, RMSD 2.43 Å
- 7DVQ chain x against the predicted model O60231: TM-score 0.93, RMSD 2.23 Å
- 7DVQ chain x against the predicted model O60231: TM-score 0.93, RMSD 2.23 Å
- 8I0T chain X against the predicted model O60231: TM-score 0.82, RMSD 3.56 Å
- 8I0V chain X against the predicted model O60231: TM-score 0.82, RMSD 3.55 Å
- 8I0U chain X against the predicted model O60231: TM-score 0.82, RMSD 3.51 Å
Elsewhere
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