UniProt O55239
Nicotinamide N-methyltransferase (O55239)
Nicotinamide N-methyltransferase (UniProt O55239), EC 2.1.1.1: 6 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 8 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- O55239
- Protein
- Nicotinamide N-methyltransferase
- EC
- 2.1.1.1
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 8 · 3 records with a druggable one
Structures
7 records of O55239 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2I62 | Mouse Nicotinamide N-methyltransferase | x-ray diffraction | A, B, C, D | — | — |
| 2I62 | Mouse nicotinamide N-methyltransferase | x-ray diffraction | A, B, C, D | — | — |
| 5XVK | Crystal structure of mouse Nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl… | x-ray diffraction | A, B | SAH, 8GC | 3 (best 0.81) |
| 5XVK | Crystal structure of mouse nicotinamide N-methyltransferase (nnmt) bound with end product, 1-methyl… | x-ray diffraction | A, B | 8GC | — |
| 5YJI | Co-crystal structure of Mouse Nicotinamide N-methyltransferase (NNMT) with small molecule analog of… | x-ray diffraction | A, B | SAH, 8WO | 4 (best 0.82) |
| 5YJI | Co-crystal structure of mouse nicotinamide N-methyltransferase (nnmt) with small molecule analog of… | x-ray diffraction | A, B | 8WO | — |
| O55239 | AlphaFold monomer V2.0 prediction for nicotinamide N-methyltransferase (O55239) | predicted | A | — | 1 (best 0.81) |
Ligands
Experiment against prediction
- 5YJI chain A against the predicted model O55239: TM-score 0.98, RMSD 0.91 Å
- 5YJI chain B against the predicted model O55239: TM-score 0.98, RMSD 0.93 Å
- 2I62 chain A against the predicted model O55239: TM-score 0.98, RMSD 0.90 Å
- 2I62 chain A against the predicted model O55239: TM-score 0.98, RMSD 0.90 Å
- 5YJI chain A against the predicted model O55239: TM-score 0.98, RMSD 0.91 Å
- 5XVK chain A against the predicted model O55239: TM-score 0.98, RMSD 1.19 Å
- 5YJI chain B against the predicted model O55239: TM-score 0.98, RMSD 0.93 Å
- 2I62 chain C against the predicted model O55239: TM-score 0.98, RMSD 0.95 Å
- 2I62 chain C against the predicted model O55239: TM-score 0.98, RMSD 0.95 Å
- 2I62 chain D against the predicted model O55239: TM-score 0.98, RMSD 1.07 Å
Elsewhere
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