UniProt O51934
Reverse gyrase (O51934)
Reverse gyrase (UniProt O51934), EC 3.6.4.12, 5.6.2.2: 13 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 51 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O51934
- Protein
- Reverse gyrase
- EC
- 3.6.4.12, 5.6.2.2
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 51 · 4 records with a druggable one
Structures
14 records of O51934 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4DDT | Thermotoga maritima reverse gyrase, C2 FORM 2 | x-ray diffraction | A | — | — |
| 4DDT | Thermotoga maritima reverse gyrase, C2 form 2 | x-ray diffraction | A | — | — |
| 4DDU | Thermotoga maritima reverse gyrase, C2 FORM 1 | x-ray diffraction | A | — | — |
| 4DDU | Thermotoga maritima reverse gyrase, C2 form 1 | x-ray diffraction | A | — | — |
| 4DDV | Thermotoga maritima reverse gyrase, triclinic form | x-ray diffraction | A, B | — | — |
| 4DDV | Thermotoga maritima reverse gyrase, triclinic form | x-ray diffraction | A, B | — | — |
| 4DDW | Thermotoga maritima reverse gyrase, c-centered orthorhombic form | x-ray diffraction | A | — | — |
| 4DDW | Thermotoga maritima reverse gyrase, C-centered orthorhombic form | x-ray diffraction | A | — | — |
| 4DDX | Thermotoga maritima reverse gyrase, primitive monoclinic form | x-ray diffraction | A, B | — | — |
| 4DDX | Thermotoga maritima reverse gyrase, primitive monoclinic form | x-ray diffraction | A, B | — | — |
| 7FSE | Crystal Structure of T. maritima reverse gyrase with a minimal latch | x-ray diffraction | A | ZN, CL | 14 (best 0.75) |
| 7FSF | Crystal structure of T. maritima reverse gyrase active site variant Y851F | x-ray diffraction | A | ZN | 15 (best 0.76) |
| 8OFB | Crystal Structure of T. maritima reverse gyrase with a minimal latch, hexagonal form | x-ray diffraction | A | ZN, SO4, CL | 10 (best 0.73) |
| O51934 | AlphaFold monomer V2.0 prediction for reverse gyrase (O51934) | predicted | A | — | 12 (best 0.76) |
Ligands
Experiment against prediction
- 7FSF chain A against the predicted model O51934: TM-score 0.98, RMSD 1.51 Å
- 8OFB chain A against the predicted model O51934: TM-score 0.98, RMSD 1.52 Å
- 7FSE chain A against the predicted model O51934: TM-score 0.98, RMSD 1.53 Å
- 4DDT chain A against the predicted model O51934: TM-score 0.98, RMSD 1.61 Å
- 4DDT chain A against the predicted model O51934: TM-score 0.98, RMSD 1.61 Å
- 4DDU chain A against the predicted model O51934: TM-score 0.98, RMSD 1.66 Å
- 4DDU chain A against the predicted model O51934: TM-score 0.98, RMSD 1.66 Å
- 4DDV chain A against the predicted model O51934: TM-score 0.97, RMSD 1.81 Å
- 4DDV chain A against the predicted model O51934: TM-score 0.97, RMSD 1.81 Å
- 4DDX chain A against the predicted model O51934: TM-score 0.97, RMSD 1.98 Å
Elsewhere
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