UniProt O43809
Cleavage and polyadenylation specificity factor subunit 5 (O43809)
Cleavage and polyadenylation specificity factor subunit 5 (UniProt O43809): 40 experimental structures and 1 predicted model on GenesisL1, 13 ligands bound, 212 pockets. Binding sites, druggability and experiment against…
- UniProt
- O43809
- Protein
- Cleavage and polyadenylation specificity factor subunit 5
- Experimental structures
- 40
- Predicted models
- 1
- Ligands
- 13
- Pockets
- 212 · 40 records with a druggable one
Structures
41 records of O43809 in the MolNFT archive: 40 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2CL3 | Crystal structure of human Cleavage and Polyadenylation Specificity Factor 5 (CPSF5) | x-ray diffraction | A | — | 1 (best 0.68) |
| 2CL3 | Crystal structure of human cleavage and polyadenylation specificity factor 5 (CPSF5) | x-ray diffraction | A | — | 1 (best 0.68) |
| 2J8Q | Crystal structure of human cleavage and polyadenylation specificity factor 5 (CPSF5) in complex… | x-ray diffraction | A, B | SO4 | 7 (best 0.68) |
| 2J8Q | Crystal structure of human cleavage and polyadenylation specificity factor 5 (CPSF5) in complex… | x-ray diffraction | A, B | SO4 | 7 (best 0.68) |
| 3BAP | Crystal Structure of the 25 kDa Subunit of Human Cleavage Factor Im | x-ray diffraction | A | — | 1 (best 0.68) |
| 3BAP | Crystal structure of the 25 kda subunit of human cleavage factor im | x-ray diffraction | A | — | 1 (best 0.68) |
| 3BHO | Crystal Structure of the 25kDa Subunit of Human Cleavage factor Im with Ap4A | x-ray diffraction | A | B4P | 1 (best 0.67) |
| 3BHO | Crystal structure of the 25KDA subunit of human cleavage factor im with AP4A | x-ray diffraction | A | B4P | 1 (best 0.67) |
| 3MDG | Crystal Structure of the 25kDa Subunit of Human Cleavage factor Im in complex with RNA UUGUAU | x-ray diffraction | A, B | — | 5 (best 0.76) |
| 3MDG | Crystal structure of the 25KDA subunit of human cleavage factor im in complex with RNA uuguau | x-ray diffraction | A, B | — | 5 (best 0.76) |
| 3MDI | Crystal Structure of the 25kDa Subunit of Human Cleavage factor Im in complex with RNA UGUAAA | x-ray diffraction | A, B | — | 6 (best 0.75) |
| 3MDI | Crystal structure of the 25KDA subunit of human cleavage factor im in complex with RNA uguaaa | x-ray diffraction | A, B | — | 6 (best 0.75) |
| 3N9U | Crystal Structure of the Complex between the 25 kDa Subunit and the 59 kDa Subunit (RRM domain) of… | x-ray diffraction | A, B | — | 8 (best 0.69) |
| 3N9U | Crystal structure of the complex between the 25 kda subunit and the 59 kda subunit (rrm domain) of… | x-ray diffraction | A, B | — | 8 (best 0.69) |
| 3P5T | CFIm25-CFIm68 complex | x-ray diffraction | A, B, C, D, E, F | — | 19 (best 0.80) |
| 3P5T | CFIM25-CFIM68 complex | x-ray diffraction | A, B, C, D, E, F | — | 19 (best 0.80) |
| 3P6Y | CF Im25-CF Im68-UGUAA complex | x-ray diffraction | A, B, E, F, I, J, M, N | — | 19 (best 0.79) |
| 3P6Y | Cf IM25-cf IM68-uguaa complex | x-ray diffraction | A, B, E, F, I, J, M, N | — | 19 (best 0.79) |
| 3Q2S | Crystal Structure of CFIm68 RRM/CFIm25 complex | x-ray diffraction | A, B | — | 6 (best 0.71) |
| 3Q2S | Crystal structure of CFIM68 RRM/CFIM25 complex | x-ray diffraction | A, B | — | 6 (best 0.71) |
| 3Q2T | Crystal Structure of CFIm68 RRM/CFIm25/RNA complex | x-ray diffraction | A, B | — | 6 (best 0.83) |
| 3Q2T | Crystal structure of CFIM68 RRM/CFIM25/RNA complex | x-ray diffraction | A, B | — | 6 (best 0.83) |
| 5R4P | PanDDA analysis group deposition -- Crystal Structure of HUMAN CLEAVAGE FACTOR IM in complex with… | x-ray diffraction | A, B | ZN, RVY | 3 (best 0.75) |
| 5R4P | Pandda analysis group deposition -- crystal structure of human cleavage factor im in complex with… | x-ray diffraction | A, B | ZN, RVY | 3 (best 0.75) |
| 5R4Q | PanDDA analysis group deposition -- Crystal Structure of HUMAN CLEAVAGE FACTOR IM in complex with… | x-ray diffraction | A, B | ZN, RW7 | 4 (best 0.75) |
| 5R4Q | Pandda analysis group deposition -- crystal structure of human cleavage factor im in complex with… | x-ray diffraction | A, B | ZN, RW7 | 4 (best 0.75) |
| 5R4R | PanDDA analysis group deposition -- Crystal Structure of HUMAN CLEAVAGE FACTOR IM in complex with… | x-ray diffraction | A, B | ZN, RWA | 3 (best 0.78) |
| 5R4R | Pandda analysis group deposition -- crystal structure of human cleavage factor im in complex with… | x-ray diffraction | A, B | ZN, RWA | 3 (best 0.78) |
| 5R4S | PanDDA analysis group deposition -- Crystal Structure of HUMAN CLEAVAGE FACTOR IM in complex with… | x-ray diffraction | A, B | RWD, ZN | 2 (best 0.75) |
| 5R4S | Pandda analysis group deposition -- crystal structure of human cleavage factor im in complex with… | x-ray diffraction | A, B | RWD, ZN | 2 (best 0.75) |
| 5R4T | PanDDA analysis group deposition -- Crystal Structure of HUMAN CLEAVAGE FACTOR IM in complex with… | x-ray diffraction | A, B | ZN, RWG | 2 (best 0.75) |
| 5R4T | Pandda analysis group deposition -- crystal structure of human cleavage factor im in complex with… | x-ray diffraction | A, B | ZN, RWG | 2 (best 0.75) |
| 5R4U | PanDDA analysis group deposition -- Crystal Structure of HUMAN CLEAVAGE FACTOR IM in complex with… | x-ray diffraction | A, B | RWM, ZN | 3 (best 0.77) |
| 5R4U | Pandda analysis group deposition -- crystal structure of human cleavage factor im in complex with… | x-ray diffraction | A, B | RWM, ZN | 3 (best 0.77) |
| 5R64 | Pandda analysis group deposition -- crystal structure of human cleavage factor im in complex with… | x-ray diffraction | A, B | ZN, M0J | 3 (best 0.75) |
| 5R65 | Pandda analysis group deposition -- crystal structure of human cleavage factor im in complex with… | x-ray diffraction | A, B | ZN, K0Y | 3 (best 0.78) |
| 5R66 | PanDDA analysis group deposition -- Crystal Structure of HUMAN CLEAVAGE FACTOR IM in complex with… | x-ray diffraction | A, B | ZN, NT7 | 3 (best 0.74) |
| 5R66 | Pandda analysis group deposition -- crystal structure of human cleavage factor im in complex with… | x-ray diffraction | A, B | ZN, NT7 | 3 (best 0.74) |
| 5R67 | PanDDA analysis group deposition -- Crystal Structure of HUMAN CLEAVAGE FACTOR IM in complex with… | x-ray diffraction | A, B | ZN, S6V | 4 (best 0.72) |
| 5R67 | Pandda analysis group deposition -- crystal structure of human cleavage factor im in complex with… | x-ray diffraction | A, B | ZN, S6V | 4 (best 0.72) |
| O43809 | AlphaFold monomer V2.0 prediction for cleavage and polyadenylation specificity factor subunit 5… | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 18 records
- B4P · Bis(adenosine)-5'-tetraphosphate · in 2 records
- NT7 · N-(2,3-dimethylphenyl)-2-(morpholin-4-yl)acetamide · in 2 records
- RVY · (5S)-5-methyl-5-[(1-phenyl-1H-1,2,3-triazol-4-yl) methyl]pyrrolidine-2,4-dione · in 2 records
- RW7 · (3S)-3,4-dimethyl-3-propyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione · in 2 records
- RWA · (5R)-3,3,5-trimethyl-5-[(1-phenyl-1H-1,2,3-triazol-4-yl)methyl]pyrrolidine-2,4-dione · in 2 records
- RWD · (4S,5R)-4-hydroxy-5-methyl-5-[(1-phenyl-1H-1,2,3-triazol-4-yl)methyl]pyrrolidin-2-one · in 2 records
- RWG · (5R)-5-{[1-(4-fluorophenyl)-1H-1,2,3-triazol-4-yl]methyl}-5-methylpyrrolidine-2,4-dione · in 2 records
- RWM · (5S)-5-methyl-5-[(3-phenyl-1,2-oxazol-5-yl)methyl]pyrrolidine-2,4-dione · in 2 records
- S6V · 1-[2-(2-oxidanylidenepyrrolidin-1-yl)ethyl]-3-phenyl-urea · in 2 records
- SO4 · Sulfate ion · in 2 records
- K0Y · methyl N-(5-methyl-1,2-oxazole-3-carbonyl)glycinate · in 1 record
- M0J · N-[(2S)-2-hydroxypropyl]-N'-phenylurea · in 1 record
Experiment against prediction
- 2J8Q chain B against the predicted model O43809: TM-score 1.00, RMSD 0.32 Å
- 2J8Q chain B against the predicted model O43809: TM-score 1.00, RMSD 0.32 Å
- 3MDG chain A against the predicted model O43809: TM-score 0.99, RMSD 0.44 Å
- 3MDG chain A against the predicted model O43809: TM-score 0.99, RMSD 0.44 Å
- 3MDI chain A against the predicted model O43809: TM-score 0.99, RMSD 0.44 Å
- 3MDI chain A against the predicted model O43809: TM-score 0.99, RMSD 0.44 Å
- 5R4P chain B against the predicted model O43809: TM-score 0.99, RMSD 0.57 Å
- 5R4P chain B against the predicted model O43809: TM-score 0.99, RMSD 0.57 Å
- 5R4T chain B against the predicted model O43809: TM-score 0.99, RMSD 0.76 Å
- 5R4T chain B against the predicted model O43809: TM-score 0.99, RMSD 0.76 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.