UniProt O43709
Probable 18S rRNA (guanine-N(7))-methyltransferase (O43709)
Probable 18S rRNA (guanine-N(7))-methyltransferase (UniProt O43709), EC 2.1.1.-: 7 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 7 pockets. Binding sites, druggability and experiment against…
- UniProt
- O43709
- Protein
- Probable 18S rRNA (guanine-N(7))-methyltransferase
- EC
- 2.1.1.-
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 7 · 5 records with a druggable one
Structures
8 records of O43709 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6G4W | Cryo-EM structure of a late human pre-40S ribosomal subunit - State A | electron microscopy | q | — | 1 (best 0.84) |
| 6G4W | Cryo-EM structure of a late human pre-40S ribosomal subunit - state a | electron microscopy | q | — | — |
| 7WTS | Cryo-EM structure of a human pre-40S ribosomal subunit - State UTP14 | electron microscopy | q | — | 2 (best 0.79) |
| 7WTT | Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-A1 (with CK1) | electron microscopy | q | SAH | 1 (best 0.83) |
| 7WTU | Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-A1 (without CK1) | electron microscopy | q | SAH | 2 (best 0.86) |
| 7WTV | Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-A2 | electron microscopy | q | SAH | 1 (best 0.88) |
| 7WTW | Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-A3 | electron microscopy | q | — | — |
| O43709 | AlphaFold monomer V2.0 prediction for probable 18S rRNA (guanine-N(7))-methyltransferase (O43709) | predicted | A | — | — |
Ligands
- SAH · S-adenosyl-L-homocysteine · in 3 records
Experiment against prediction
- 7WTW chain q against the predicted model O43709: TM-score 0.97, RMSD 0.95 Å
- 6G4W chain q against the predicted model O43709: TM-score 0.96, RMSD 1.26 Å
- 6G4W chain q against the predicted model O43709: TM-score 0.96, RMSD 1.26 Å
- 7WTV chain q against the predicted model O43709: TM-score 0.85, RMSD 0.75 Å
- 7WTU chain q against the predicted model O43709: TM-score 0.84, RMSD 0.77 Å
- 7WTT chain q against the predicted model O43709: TM-score 0.84, RMSD 0.78 Å
- 7WTS chain q against the predicted model O43709: TM-score 0.84, RMSD 0.79 Å
Elsewhere
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