UniProt O43612
Orexin (O43612)
Orexin (UniProt O43612): 10 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 5 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O43612
- Protein
- Orexin
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 5 · 0 records with a druggable one
Structures
11 records of O43612 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1CQ0 | Solution structure of a human hypocretin-2/OREXIN-B'SOLUTION structure of a human… | solution nmr | A | — | — |
| 1CQ0 | Solution structure of a human hypocretin-2/OREXIN-B'SOLUTION structure of a human… | solution nmr | A | — | — |
| 1R02 | Solution structure of Human Orexin-A:Regulator of Appetite and Wakefulness | solution nmr | A | — | — |
| 1R02 | Solution structure of human orexin-A:REGULATOR of appetite and wakefulness | solution nmr | A | — | — |
| 1UVQ | Crystal structure of HLA-DQ0602 in complex with a hypocretin peptide | x-ray diffraction | C | NAG | 2 (best 0.27) |
| 1UVQ | Crystal structure of HLA-DQ0602 in complex with a hypocretin peptide | x-ray diffraction | C | — | — |
| 1WSO | The solution structures of human Orexin-A | solution nmr | A | — | — |
| 1WSO | The solution structures of human orexin-a | solution nmr | A | — | — |
| 7L1U | Orexin Receptor 2 (OX2R) in Complex with G Protein and Natural Peptide-Agonist Orexin B (OxB) | electron microscopy | L | — | 1 (best 0.37) |
| 7L1U | Orexin receptor 2 (OX2R) in complex with G protein and natural peptide-agonist orexin B (oxb) | electron microscopy | L | NH2 | — |
| O43612 | AlphaFold monomer V2.0 prediction for orexin (O43612) | predicted | A | — | 2 (best 0.31) |
Ligands
Experiment against prediction
- 1R02 chain A against the predicted model O43612: TM-score 0.41, RMSD 1.82 Å
- 1R02 chain A against the predicted model O43612: TM-score 0.41, RMSD 1.82 Å
- 7L1U chain L against the predicted model O43612: TM-score 0.37, RMSD 1.60 Å
- 7L1U chain L against the predicted model O43612: TM-score 0.37, RMSD 1.60 Å
- 1CQ0 chain A against the predicted model O43612: TM-score 0.35, RMSD 2.05 Å
- 1CQ0 chain A against the predicted model O43612: TM-score 0.35, RMSD 2.05 Å
- 1WSO chain A against the predicted model O43612: TM-score 0.33, RMSD 3.08 Å
- 1WSO chain A against the predicted model O43612: TM-score 0.33, RMSD 3.08 Å
- 1UVQ chain C against the predicted model O43612: TM-score 0.16, RMSD 1.96 Å
- 1UVQ chain C against the predicted model O43612: TM-score 0.16, RMSD 1.96 Å
Elsewhere
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