UniProt O43426
Synaptojanin-1 (O43426)
Synaptojanin-1 (UniProt O43426), EC 3.1.3.36: 10 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 44 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O43426
- Protein
- Synaptojanin-1
- EC
- 3.1.3.36
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 44 · 3 records with a druggable one
Structures
11 records of O43426 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1W80 | Crystal structure of the alpha-adaptin appendage domain, from the AP2 adaptor complex, bound to 2… | x-ray diffraction | P, Q | — | — |
| 1W80 | Crystal structure of the alpha-adaptin appendage domain, from the AP2 adaptor complex, bound to 2… | x-ray diffraction | P, Q | — | — |
| 2DNR | Solution structure of RNA binding domain in Synaptojanin 1 | solution nmr | A | — | — |
| 2DNR | Solution structure of RNA binding domain in synaptojanin 1 | solution nmr | A | — | — |
| 2VJ0 | Crystal structure of the alpha-adaptin appendage domain, from the AP2 adaptor complex, in complex… | x-ray diffraction | P | — | — |
| 2VJ0 | Crystal structure of the alpha-adaptin appendage domain, from the AP2 adaptor complex, in complex… | x-ray diffraction | P | — | — |
| 7A0V | Crystal structure of the 5-phosphatase domain of Synaptojanin1 in complex with a nanobody | x-ray diffraction | A, C, E | PO4, MG | 15 (best 0.81) |
| 7A0V | Crystal structure of the 5-phosphatase domain of SYNAPTOJANIN1 in complex with a nanobody | x-ray diffraction | A, C, E | PO4, MG | — |
| 7A17 | Crystal structure of the 5-phosphatase domain of Synaptojanin1 bound to its substrate… | x-ray diffraction | A, C, E | IP9, MG, PO4 | 16 (best 0.83) |
| 7A17 | Crystal structure of the 5-phosphatase domain of SYNAPTOJANIN1 bound to its substrate… | x-ray diffraction | A, C, E | IP9, MG, PO4 | — |
| O43426 | AlphaFold monomer V2.0 prediction for synaptojanin-1 (O43426) | predicted | A | — | 13 (best 0.83) |
Ligands
Experiment against prediction
- 7A17 chain E against the predicted model O43426: TM-score 0.98, RMSD 0.96 Å
- 7A17 chain E against the predicted model O43426: TM-score 0.98, RMSD 0.96 Å
- 7A0V chain E against the predicted model O43426: TM-score 0.98, RMSD 1.21 Å
- 7A0V chain E against the predicted model O43426: TM-score 0.98, RMSD 1.21 Å
- 7A0V chain C against the predicted model O43426: TM-score 0.97, RMSD 1.41 Å
- 7A0V chain C against the predicted model O43426: TM-score 0.97, RMSD 1.41 Å
- 7A17 chain C against the predicted model O43426: TM-score 0.97, RMSD 1.53 Å
- 7A17 chain C against the predicted model O43426: TM-score 0.97, RMSD 1.53 Å
- 7A0V chain A against the predicted model O43426: TM-score 0.96, RMSD 1.73 Å
- 7A0V chain A against the predicted model O43426: TM-score 0.96, RMSD 1.73 Å
Elsewhere
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