UniProt O43181

NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (O43181)

NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (UniProt O43181): 6 experimental structures and 1 predicted model on GenesisL1, 17 pockets. Binding sites, druggability and experiment against prediction…

UniProt: O43181
Protein: NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
Experimental structures: 6
Predicted models: 1
Pockets: 17 · 4 records with a druggable one

Structures

7 records of O43181 in the MolNFT archive: 6 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
5XTB	Cryo-EM structure of human respiratory complex I matrix arm	electron microscopy	L	—	6 (best 0.89)
5XTB	Cryo-EM structure of human respiratory complex I matrix arm	electron microscopy	L	—	—
5XTD	Cryo-EM structure of human respiratory complex I	electron microscopy	L	—	5 (best 0.86)
5XTD	Cryo-EM structure of human respiratory complex I	electron microscopy	L	—	—
5XTH	Cryo-EM structure of human respiratory supercomplex I1III2IV1	electron microscopy	L	—	4 (best 0.89)
5XTI	Cryo-EM architecture of human respiratory chain megacomplex-I2III2IV2	electron microscopy	L, BL	—	2 (best 0.89)
O43181	AlphaFold monomer V2.0 prediction for NADH dehydrogenase [ubiquinone] iron-sulfur protein 4…	predicted	A	—	—

Experiment against prediction

5XTD chain L against the predicted model O43181: TM-score 0.96, RMSD 0.92 Å
5XTD chain L against the predicted model O43181: TM-score 0.96, RMSD 0.92 Å
5XTB chain L against the predicted model O43181: TM-score 0.96, RMSD 0.92 Å
5XTB chain L against the predicted model O43181: TM-score 0.96, RMSD 0.92 Å
5XTH chain L against the predicted model O43181: TM-score 0.96, RMSD 0.92 Å
5XTI chain BL against the predicted model O43181: TM-score 0.96, RMSD 0.92 Å
5XTI chain L against the predicted model O43181: TM-score 0.96, RMSD 0.92 Å

Elsewhere

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