UniProt O38716
Protease (O38716)
Protease (UniProt O38716), EC 3.4.23.16: 12 experimental structures on GenesisL1, 6 ligands bound, 3 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- O38716
- Protein
- Protease
- EC
- 3.4.23.16
- Experimental structures
- 12
- Predicted models
- 0
- Ligands
- 6
- Pockets
- 3 · 3 records with a druggable one
Structures
12 records of O38716 in the MolNFT archive: 12 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2FGU | X-ray crystal structure of HIV-1 Protease T80S variant in complex with the inhibitor saquinavir… | x-ray diffraction | A, B | PO4, QNC, DIQ, NTB | 1 (best 0.65) |
| 2FGU | X-ray crystal structure of HIV-1 protease T80S variant in complex with the inhibitor saquinavir… | x-ray diffraction | A, B | — | — |
| 2FGV | X-ray crystal structure of HIV-1 Protease T80N variant in complex with the inhibitor saquinavir… | x-ray diffraction | A, B | PO4, QNC, DIQ, NTB | 1 (best 0.63) |
| 2FGV | X-ray crystal structure of HIV-1 protease T80N variant in complex with the inhibitor saquinavir… | x-ray diffraction | A, B | — | — |
| 2FNS | Crystal structure of wild-type inactive (D25N) HIV-1 protease complexed with wild-type HIV-1 NC-p1… | x-ray diffraction | A, B | PO4 | — |
| 2FNS | Crystal structure of wild-type inactive (D25N) HIV-1 protease complexed with wild-type HIV-1 nc-P1… | x-ray diffraction | A, B | — | — |
| 2FNT | Crystal structure of a drug-resistant (V82A) inactive (D25N) HIV-1 protease complexed with AP2V… | x-ray diffraction | A, B | PO4 | — |
| 2FNT | Crystal structure of a drug-resistant (V82A) inactive (D25N) HIV-1 protease complexed with AP2V… | x-ray diffraction | A, B | — | — |
| 2JE4 | Atomic-resolution crystal structure of chemically-synthesized HIV-1 protease in complex with JG-365 | x-ray diffraction | A, B | SO4 | — |
| 2JE4 | Atomic-resolution crystal structure of chemically-synthesized HIV-1 protease in complex with jg-365 | x-ray diffraction | A, B | — | — |
| 3I7E | Co-crystal structure of HIV-1 protease bound to a mutant resistant inhibitor UIC-98038 | x-ray diffraction | A, B | DJR | 1 (best 0.71) |
| 3I7E | Co-crystal structure of HIV-1 protease bound to a mutant resistant inhibitor uic-98038 | x-ray diffraction | A, B | — | — |
Ligands
- PO4 · Phosphate ion · in 4 records
- DIQ · 2-methyl-decahydro-isoquinoline-3-carboxylic acid · in 2 records
- NTB · Tertiary-butylamine · in 2 records
- QNC · quinoline-2-carboxylic acid · in 2 records
- DJR · (3r,3as,6ar)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-1-benzyl-2-hydroxy-3-{isobutyl[(4-methoxyphenyl) sulfonyl]amino}propyl]carbamate · in 1 record
- SO4 · Sulfate ion · in 1 record
Elsewhere
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