UniProt O34757
Sensor histidine kinase DesK (O34757)
Sensor histidine kinase DesK (UniProt O34757), EC 2.7.13.3: 25 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 76 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- O34757
- Protein
- Sensor histidine kinase DesK
- EC
- 2.7.13.3
- Experimental structures
- 25
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 76 · 6 records with a druggable one
Structures
26 records of O34757 in the MolNFT archive: 25 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3EHF | Crystal structure of DesKC in complex with AMP-PCP | x-ray diffraction | A, B, C, D | — | — |
| 3EHF | Crystal structure of deskc in complex with AMP-pcp | x-ray diffraction | A, B, C, D | — | — |
| 3EHG | Crystal structure of the ATP-binding domain of DesK in complex with ATP | x-ray diffraction | A | — | — |
| 3EHG | Crystal structure of the ATP-binding domain of desk in complex with ATP | x-ray diffraction | A | — | — |
| 3EHH | Crystal structure of DesKC-H188V in complex with ADP | x-ray diffraction | A, B | — | — |
| 3EHH | Crystal structure of deskc-H188V in complex with ADP | x-ray diffraction | A, B | — | — |
| 3EHJ | Crystal structure of DesKC-H188V in complex with AMP-PCP | x-ray diffraction | A, B | — | — |
| 3EHJ | Crystal structure of deskc-H188V in complex with AMP-pcp | x-ray diffraction | A, B | — | — |
| 3GIE | Crystal structure of DesKC_H188E in complex with AMP-PCP | x-ray diffraction | A, B | — | — |
| 3GIE | Crystal structure of DESKC_H188E in complex with AMP-pcp | x-ray diffraction | A, B | — | — |
| 3GIF | Crystal structure of DesKC_H188E in complex with ADP | x-ray diffraction | A, B | — | — |
| 3GIF | Crystal structure of DESKC_H188E in complex with ADP | x-ray diffraction | A, B | — | — |
| 3GIG | Crystal structure of phosphorylated DesKC in complex with AMP-PCP | x-ray diffraction | A, B | — | — |
| 3GIG | Crystal structure of phosphorylated deskc in complex with AMP-pcp | x-ray diffraction | A, B | — | — |
| 5IUJ | Crystal structure of the DesK-DesR complex in the phosphotransfer state with low Mg2+ (20 mM) | x-ray diffraction | A, B, D, E | ACP, MG | 12 (best 0.75) |
| 5IUJ | Crystal structure of the desk-desr complex in the phosphotransfer state with low MG2+ (20 mm) | x-ray diffraction | A, B, D, E | — | — |
| 5IUK | Crystal structure of the DesK-DesR complex in the phosphotransfer state with high Mg2+ (150 mM) | x-ray diffraction | A, B, D, E | ACP, MG | 14 (best 0.73) |
| 5IUK | Crystal structure of the desk-desr complex in the phosphotransfer state with high MG2+ (150 mm) | x-ray diffraction | A, B, D, E | — | — |
| 5IUL | Crystal structure of the DesK-DesR complex in the phosphotransfer state with high Mg2+ (150 mM) and… | x-ray diffraction | A, B, D, E | ACP, MG | 16 (best 0.67) |
| 5IUL | Crystal structure of the desk-desr complex in the phosphotransfer state with high MG2+ (150 mm) and… | x-ray diffraction | A, B, D, E | — | — |
| 5IUM | Crystal structure of phosphorylated DesKC | x-ray diffraction | A, B | ACP, MG | 6 (best 0.64) |
| 5IUM | Crystal structure of phosphorylated deskc | x-ray diffraction | A, B | — | — |
| 5IUN | Crystal structure of the desk-desr complex in the phosphatase state | x-ray diffraction | A, B, E | — | — |
| 7SSI | Crystal structure of the DESK:DESR-Q10A complex in the phosphotransfer state | x-ray diffraction | A, B, D, E | ACP, MG | 12 (best 0.70) |
| 7SSJ | Crystal structure of the DesK-DesR complex in the phosphatase state | x-ray diffraction | A, C, D | ACP, MG, BEF | 16 (best 0.77) |
| O34757 | AlphaFold monomer V2.0 prediction for sensor histidine kinase desk (O34757) | predicted | A | — | — |
Ligands
Experiment against prediction
- 3EHG chain A against the predicted model O34757: TM-score 0.97, RMSD 0.94 Å
- 3EHG chain A against the predicted model O34757: TM-score 0.97, RMSD 0.94 Å
- 3EHF chain C against the predicted model O34757: TM-score 0.93, RMSD 0.73 Å
- 3EHF chain C against the predicted model O34757: TM-score 0.93, RMSD 0.73 Å
- 3GIF chain B against the predicted model O34757: TM-score 0.81, RMSD 2.02 Å
- 3GIF chain B against the predicted model O34757: TM-score 0.81, RMSD 2.02 Å
- 3EHF chain D against the predicted model O34757: TM-score 0.71, RMSD 2.88 Å
- 3EHF chain D against the predicted model O34757: TM-score 0.71, RMSD 2.88 Å
- 3EHF chain A against the predicted model O34757: TM-score 0.71, RMSD 2.76 Å
- 3EHF chain A against the predicted model O34757: TM-score 0.71, RMSD 2.76 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.