UniProt O32164
Cysteine desulfurase SufS (O32164)
Cysteine desulfurase SufS (UniProt O32164), EC 2.8.1.7: 31 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 31 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O32164
- Protein
- Cysteine desulfurase SufS
- EC
- 2.8.1.7
- Experimental structures
- 31
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 31 · 4 records with a druggable one
Structures
32 records of O32164 in the MolNFT archive: 31 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5J8Q | Crystal Structure of the Cysteine Desulfurase SufS of Bacillus subtilis | x-ray diffraction | A | PLP | — |
| 5J8Q | Crystal structure of the cysteine desulfurase sufs of bacillus subtilis | x-ray diffraction | A | — | — |
| 5XT5 | Sufs-sufu complex from bacillus subtilis | x-ray diffraction | A, B | ZN, PLP | — |
| 5XT6 | A sulfur-transferring catalytic intermediate of SufS-SufU complex from Bacillus subtilis | x-ray diffraction | A, B | ZN, PDA | 11 (best 0.77) |
| 5XT6 | A sulfur-transferring catalytic intermediate of sufs-sufu complex from bacillus subtilis | x-ray diffraction | A, B | ZN | — |
| 5ZS9 | Sufs from bacillus subtilis in the resting state | x-ray diffraction | A | — | — |
| 5ZSK | Sufs from bacillus subtilis soaked with L-cysteine for 63 sec | x-ray diffraction | A | — | — |
| 5ZSO | Sufs from bacillus subtilis, soaked with L-cysteine for 90 sec | x-ray diffraction | A | — | — |
| 6KFY | Sufs from bacillus subtilis in a resting state at 1.96 ångström resolution | x-ray diffraction | A | SO4 | — |
| 6KFZ | SufS from Bacillus subtilis, soaked with L-cysteine for 90 sec at 1.96 angstrom resolution | x-ray diffraction | A | C6P | 2 (best 0.45) |
| 6KFZ | Sufs from bacillus subtilis, soaked with L-cysteine for 90 sec at 1.96 ångström resolution | x-ray diffraction | A | — | — |
| 7CEO | Crystal structure of pmp-bound form of cysteine desulfurase sufs from bacillus subtilis | x-ray diffraction | A | PMP | — |
| 7CEP | Crystal structure of L-cycloserine-bound form of cysteine desulfurase SufS from Bacillus subtilis | x-ray diffraction | A | 7TS | 3 (best 0.50) |
| 7CEP | Crystal structure of L-cycloserine-bound form of cysteine desulfurase sufs from bacillus subtilis | x-ray diffraction | A | — | — |
| 7CEQ | Crystal structure of cysteine desulfurase sufs H121A from bacillus subtilis | x-ray diffraction | A | — | — |
| 7CER | Crystal structure of D-cycloserine-bound form of cysteine desulfurase sufs H121A from bacillus… | x-ray diffraction | A | — | — |
| 7CES | Crystal structure of L-cycloserine-bound form of cysteine desulfurase SufS H121A from Bacillus… | x-ray diffraction | A | 7TS | 3 (best 0.51) |
| 7CES | Crystal structure of L-cycloserine-bound form of cysteine desulfurase sufs H121A from bacillus… | x-ray diffraction | A | — | — |
| 7E6A | Crystal structure of cysteine desulfurase sufs C361A from bacillus subtilis | x-ray diffraction | A | — | — |
| 7E6B | Crystal structure of pmp-bound form of cysteine desulfurase sufs C361A from bacillus subtilis | x-ray diffraction | A | PMP | — |
| 7E6C | Crystal structure of L-cycloserine-bound form of cysteine desulfurase sufs C361A from bacillus… | x-ray diffraction | A | — | — |
| 7E6D | Crystal structure of cysteine desulfurase sufs R376A from bacillus subtilis | x-ray diffraction | A | — | — |
| 7E6E | Crystal structure of pmp-bound form of cysteine desulfurase sufs R376A from bacillus subtilis in… | x-ray diffraction | A | PMP | — |
| 7E6F | Crystal structure of pmp-bound form of cysteine desulfurase sufs R376A from bacillus subtilis in… | x-ray diffraction | A | PMP | — |
| 7XEJ | SufS with D-cysteine for 5 min | x-ray diffraction | A | 9PV | 3 (best 0.52) |
| 7XEK | SufS with D-cysteine for 30 min | x-ray diffraction | A | 9YX | 2 (best 0.50) |
| 7XEL | SufS soaked with D-penicillamine | x-ray diffraction | A | — | 1 (best 0.38) |
| 7XEN | SufS with L-penicillamine | x-ray diffraction | A | — | — |
| 7XEP | SufS with L-propargylglycine | x-ray diffraction | A | EIL | — |
| 7XET | SufS with beta-cyano-L-alanine | x-ray diffraction | A | 9YC | 3 (best 0.48) |
| 7YB3 | SufS with D-cysteine for 1 min | x-ray diffraction | A | — | 1 (best 0.37) |
| O32164 | AlphaFold monomer V2.0 prediction for cysteine desulfurase sufs (O32164) | predicted | A | — | 2 (best 0.51) |
Ligands
- PMP · 4'-deoxy-4'-aminopyridoxal-5'-phosphate · in 4 records
- ZN · Zinc ion · in 3 records
- 7TS · (5-hydroxy-6-methyl-4-{[(3-oxo-2,3-dihydro-1,2-oxazol-4-yl)amino]methyl}pyridin-3-yl)methyl dihydrogen phosphate · in 2 records
- PLP · Pyridoxal-5'-phosphate · in 2 records
- 9PV · (2~{S})-2-[(~{E})-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]-3-sulfanyl-propanoic acid · in 1 record
- 9YC · (2~{E})-3-cyano-2-[[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylimino]propanoic acid · in 1 record
- 9YX · (2~{S},4~{S})-2-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]-1,3-thiazolidine-4-carboxylic acid · in 1 record
- C6P · N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-L-cysteine · in 1 record
- EIL · [6-methyl-4-[[(5-methyl-2-oxidanylidene-furan-3-ylidene)amino]methyl]-5-oxidanyl-pyridin-3-yl]methyl dihydrogen phosphate · in 1 record
- PDA · 2-[(3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-ylmethyl)-amino]-propionic acid · in 1 record
- SO4 · Sulfate ion · in 1 record
Experiment against prediction
- 7YB3 chain A against the predicted model O32164: TM-score 1.00, RMSD 0.42 Å
- 7XEJ chain A against the predicted model O32164: TM-score 0.98, RMSD 0.43 Å
- 6KFY chain A against the predicted model O32164: TM-score 0.99, RMSD 0.44 Å
- 7XET chain A against the predicted model O32164: TM-score 1.00, RMSD 0.44 Å
- 7CES chain A against the predicted model O32164: TM-score 0.98, RMSD 0.45 Å
- 7CES chain A against the predicted model O32164: TM-score 0.97, RMSD 0.45 Å
- 7E6C chain A against the predicted model O32164: TM-score 0.98, RMSD 0.45 Å
- 7E6A chain A against the predicted model O32164: TM-score 0.98, RMSD 0.44 Å
- 7E6E chain A against the predicted model O32164: TM-score 0.98, RMSD 0.45 Å
- 7XEK chain A against the predicted model O32164: TM-score 0.98, RMSD 0.45 Å
Elsewhere
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