UniProt O31266

1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase (O31266)

1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase (UniProt O31266), EC 1.13.11.48: 8 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 47 pockets. Binding sites, druggability and experiment against…

UniProt: O31266
Protein: 1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase
EC: 1.13.11.48
Experimental structures: 8
Predicted models: 1
Ligands: 7
Pockets: 47 · 6 records with a druggable one

Structures

9 records of O31266 in the MolNFT archive: 8 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
4CFS	Crystal structure of the cofactor-devoid 1-H-3-hydroxy-4- oxoquinaldine 2,4-dioxygenase (hod)…	x-ray diffraction	A, B, C, D	—	—
4CFS	Crystal structure of the cofactor-devoid 1-H-3-hydroxy-4- oxoquinaldine 2,4-dioxygenase (hod)…	x-ray diffraction	A, B, C, D	—	—
7OJM	Crystal structure of the cofactor-devoid 1-H-3-hydroxy-4- oxoquinaldine 2,4-dioxygenase (hod)…	x-ray diffraction	AAA, BBB	VFH, K, SRT, NA	6 (best 0.72)
7OKZ	Crystal structure of the cofactor-devoid 1-H-3-hydroxy-4- oxoquinaldine 2,4-dioxygenase (hod)…	x-ray diffraction	AAA, BBB	VFH, K	5 (best 0.73)
8A97	ROOM TEMPERATURE CRYSTAL STRUCTURE OF THE COFACTOR-DEVOID 1-H-3-HYDROXY-4- OXOQUINALDINE…	x-ray diffraction	AAA, BBB, CCC, DDD	XE	14 (best 0.79)
8ORO	Crystal structure of the cofactor-devoid 1-H-3-hydroxy-4- oxoquinaldine 2,4-dioxygenase (hod) S101A…	x-ray diffraction	AAA, BBB	VFH, OXY, NA	8 (best 0.69)
8OXN	Crystal structure of the cofactor-devoid 1-H-3-hydroxy-4- oxoquinaldine 2,4-dioxygenase (hod) S101A…	x-ray diffraction	AAA, BBB, CCC, DDD	VFH, SRT	7 (best 0.80)
8OXT	Crystal structure of the cofactor-devoid 1-H-3-hydroxy-4- oxoquinaldine 2,4-dioxygenase (hod) H251A…	x-ray diffraction	AAA, BBB	ZZ8, SRT, K	7 (best 0.71)
O31266	AlphaFold monomer V2.0 prediction for 1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase (O31266)	predicted	A	—	—

Ligands

VFH · 2-methyl-quinolin-4(1H)-one · in 4 records
K · Potassium ion · in 3 records
SRT · S,R meso-tartaric acid · in 3 records
NA · Sodium ion · in 2 records
OXY · Oxygen molecule · in 1 record
XE · Xenon · in 1 record
ZZ8 · 2-(acetylamino)benzoic acid · in 1 record

Experiment against prediction

4CFS chain D against the predicted model O31266: TM-score 1.00, RMSD 0.17 Å
4CFS chain D against the predicted model O31266: TM-score 1.00, RMSD 0.17 Å
4CFS chain A against the predicted model O31266: TM-score 1.00, RMSD 0.17 Å
4CFS chain A against the predicted model O31266: TM-score 1.00, RMSD 0.17 Å
8OXN chain BBB against the predicted model O31266: TM-score 1.00, RMSD 0.19 Å
8OXN chain DDD against the predicted model O31266: TM-score 1.00, RMSD 0.20 Å
8ORO chain BBB against the predicted model O31266: TM-score 1.00, RMSD 0.20 Å
8OXT chain AAA against the predicted model O31266: TM-score 1.00, RMSD 0.20 Å
8ORO chain AAA against the predicted model O31266: TM-score 1.00, RMSD 0.20 Å
8A97 chain AAA against the predicted model O31266: TM-score 1.00, RMSD 0.21 Å

Elsewhere

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