UniProt O15553
Pyrin (O15553)
Pyrin (UniProt O15553): 9 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 15 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O15553
- Protein
- Pyrin
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 15 · 3 records with a druggable one
Structures
10 records of O15553 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2MPC | Solution structure of the pyrin domain of human Pyrin | solution nmr | A | — | — |
| 2MPC | Solution structure of the pyrin domain of human pyrin | solution nmr | A | — | — |
| 2WL1 | Pyrin PrySpry domain | x-ray diffraction | A | — | — |
| 2WL1 | Pyrin pryspry domain | x-ray diffraction | A | — | — |
| 4CG4 | Crystal structure of the CHS-B30.2 domains of TRIM20 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4CG4 | Crystal structure of the chs-B30.2 domains of TRIM20 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 8C28 | 14-3-3 in complex with PyrinpS208pS242 | x-ray diffraction | CCC, DDD, PPP | — | 2 (best 0.49) |
| 8C30 | Crystal structure of 14-3-3 in complex with PyrinpS242 and a protein/peptide interface fragment | x-ray diffraction | PPP | 463 | 3 (best 0.51) |
| 8SDJ | Hydrophobic Interactions Drive the Tetrameric Assembly of the TRIM20 Coiled-Coil Domain | x-ray diffraction | A, B, C, D | — | 7 (best 0.87) |
| O15553 | AlphaFold monomer V2.0 prediction for pyrin (O15553) | predicted | A | — | 3 (best 0.59) |
Ligands
- 463 · N-[3-(aminomethyl)phenyl]acetamide · in 1 record
Experiment against prediction
- 2WL1 chain A against the predicted model O15553: TM-score 0.99, RMSD 0.62 Å
- 2WL1 chain A against the predicted model O15553: TM-score 0.99, RMSD 0.62 Å
- 2MPC chain A against the predicted model O15553: TM-score 0.93, RMSD 0.99 Å
- 2MPC chain A against the predicted model O15553: TM-score 0.93, RMSD 0.99 Å
- 4CG4 chain B against the predicted model O15553: TM-score 0.93, RMSD 2.03 Å
- 4CG4 chain B against the predicted model O15553: TM-score 0.93, RMSD 2.03 Å
- 4CG4 chain A against the predicted model O15553: TM-score 0.92, RMSD 1.82 Å
- 4CG4 chain A against the predicted model O15553: TM-score 0.92, RMSD 1.82 Å
- 4CG4 chain E against the predicted model O15553: TM-score 0.88, RMSD 2.88 Å
- 4CG4 chain E against the predicted model O15553: TM-score 0.88, RMSD 2.88 Å
Elsewhere
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