UniProt O15550
Lysine-specific demethylase 6A (O15550)
Lysine-specific demethylase 6A (UniProt O15550), EC 1.14.11.-: 8 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 20 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- O15550
- Protein
- Lysine-specific demethylase 6A
- EC
- 1.14.11.-
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 20 · 2 records with a druggable one
Structures
9 records of O15550 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3AVR | Catalytic fragment of UTX/KDM6A bound with histone H3K27me3 peptide, N-oxyalylglycine, and Ni(II) | x-ray diffraction | A | — | — |
| 3AVR | Catalytic fragment of UTX/KDM6A bound with histone H3K27ME3 peptide, N-oxyalylglycine, and NI(II) | x-ray diffraction | A | — | — |
| 3AVS | Catalytic fragment of UTX/KDM6A bound with N-oxyalylglycine, and Ni(II) | x-ray diffraction | A | — | — |
| 3AVS | Catalytic fragment of UTX/KDM6A bound with N-oxyalylglycine, and NI(II) | x-ray diffraction | A | — | — |
| 6FUK | Crystal structure of utx complexed with 5-carboxy-8-hydroxyquinoline | x-ray diffraction | A | MN, 8XQ, ZN, SO4 | — |
| 6FUL | Crystal structure of utx complexed with 5-hydroxy-4-keto-1-methyl- picolinate | x-ray diffraction | A | E7Z, MN, ZN, SO4 | — |
| 6G8F | Crystal structure of UTX complexed with GSK-J1 | x-ray diffraction | A | MN, ZN, K0I, CL | 6 (best 0.71) |
| 6G8F | Crystal structure of utx complexed with gsk-J1 | x-ray diffraction | A | MN, ZN, K0I, CL | — |
| O15550 | AlphaFold monomer V2.0 prediction for lysine-specific demethylase 6A (O15550) | predicted | A | — | 14 (best 0.81) |
Ligands
- MN · Manganese (II) ion · in 4 records
- ZN · Zinc ion · in 4 records
- CL · Chloride ion · in 2 records
- K0I · 3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoic acid · in 2 records
- SO4 · Sulfate ion · in 2 records
- 8XQ · 8-hydroxyquinoline-5-carboxylic acid · in 1 record
- E7Z · 1-methyl-5-oxidanyl-4-oxidanylidene-pyridine-2-carboxylic acid · in 1 record
Experiment against prediction
- 6FUK chain A against the predicted model O15550: TM-score 1.00, RMSD 0.42 Å
- 3AVS chain A against the predicted model O15550: TM-score 1.00, RMSD 0.46 Å
- 3AVS chain A against the predicted model O15550: TM-score 1.00, RMSD 0.46 Å
- 6G8F chain A against the predicted model O15550: TM-score 1.00, RMSD 0.46 Å
- 6G8F chain A against the predicted model O15550: TM-score 1.00, RMSD 0.46 Å
- 6FUL chain A against the predicted model O15550: TM-score 1.00, RMSD 0.51 Å
- 3AVR chain A against the predicted model O15550: TM-score 0.99, RMSD 0.95 Å
- 3AVR chain A against the predicted model O15550: TM-score 0.99, RMSD 0.95 Å
Elsewhere
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