UniProt O15371
Eukaryotic translation initiation factor 3 subunit D (O15371)
Eukaryotic translation initiation factor 3 subunit D (UniProt O15371): 13 experimental structures and 1 predicted model on GenesisL1, 20 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O15371
- Protein
- Eukaryotic translation initiation factor 3 subunit D
- Experimental structures
- 13
- Predicted models
- 1
- Pockets
- 20 · 10 records with a druggable one
Structures
14 records of O15371 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6YBD | Structure of a human 48S translational initiation complex - EIF3 | electron microscopy | x | — | — |
| 6YBS | Structure of a human 48S translational initiation complex - head | electron microscopy | x | — | — |
| 6ZON | SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 1 | electron microscopy | D | — | 3 (best 0.85) |
| 6ZVJ | Structure of a human ABCE1-bound 43S pre-initiation complex - State II | electron microscopy | D | — | 2 (best 0.84) |
| 7A09 | Structure of a human ABCE1-bound 43S pre-initiation complex - State III | electron microscopy | N | — | — |
| 7QP6 | Structure of the human 48S initiation complex in open state (h48S AUG open) | electron microscopy | x | — | 3 (best 0.86) |
| 7QP7 | Structure of the human 48S initiation complex in closed state (h48S AUG closed) | electron microscopy | x | — | 2 (best 0.86) |
| 8OZ0 | Structure of a human 48S translation initiation complex with eIF4F and eIF4A | electron microscopy | x | — | 2 (best 0.85) |
| 8PJ1 | Structure of human 48S translation initiation complex in open codon scanning state (48S-1) | electron microscopy | x | — | 1 (best 0.85) |
| 8PJ6 | Structure of human 48S translation initiation complex with initiator tRNA, eIF1A and eIF3… | electron microscopy | x | — | 2 (best 0.85) |
| 8PPL | MERS-CoV Nsp1 bound to the human 43S pre-initiation complex | electron microscopy | Ix | — | 2 (best 0.86) |
| 8RG0 | Structure of human eIF3 core from closed 48S translation initiation complex | electron microscopy | x | — | 2 (best 0.85) |
| 8XXN | Cryo-EM structure of the human 43S ribosome with PDCD4 | electron microscopy | 3N | — | 1 (best 0.82) |
| O15371 | AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 3 subunit D (O15371) | predicted | A | — | — |
Experiment against prediction
- 6YBS chain x against the predicted model O15371: TM-score 0.96, RMSD 1.52 Å
- 8PJ6 chain x against the predicted model O15371: TM-score 0.82, RMSD 1.50 Å
- 8PJ1 chain x against the predicted model O15371: TM-score 0.82, RMSD 1.64 Å
- 7QP7 chain x against the predicted model O15371: TM-score 0.82, RMSD 1.75 Å
- 7QP6 chain x against the predicted model O15371: TM-score 0.82, RMSD 1.77 Å
- 8PPL chain Ix against the predicted model O15371: TM-score 0.81, RMSD 0.26 Å
- 8XXN chain 3N against the predicted model O15371: TM-score 0.80, RMSD 1.05 Å
- 6ZVJ chain D against the predicted model O15371: TM-score 0.80, RMSD 1.14 Å
- 7A09 chain N against the predicted model O15371: TM-score 0.80, RMSD 1.20 Å
- 6ZON chain D against the predicted model O15371: TM-score 0.79, RMSD 1.50 Å
Elsewhere
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