UniProt O15054
Lysine-specific demethylase 6B (O15054)
Lysine-specific demethylase 6B (UniProt O15054), EC 1.14.11.-: 12 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 32 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- O15054
- Protein
- Lysine-specific demethylase 6B
- EC
- 1.14.11.-
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 32 · 4 records with a druggable one
Structures
13 records of O15054 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2XUE | Crystal structure of JMJD3 | x-ray diffraction | A, B | — | — |
| 2XUE | Crystal structure of JMJD3 | x-ray diffraction | A, B | — | — |
| 2XXZ | Crystal structure of the human JMJD3 jumonji domain | x-ray diffraction | A, B | — | — |
| 2XXZ | Crystal structure of the human JMJD3 jumonji domain | x-ray diffraction | A, B | — | — |
| 4ASK | Crystal structure of JMJD3 with gsk-J1 | x-ray diffraction | A, B | — | — |
| 4ASK | Crystal structure of JMJD3 with gsk-J1 | x-ray diffraction | A, B | — | — |
| 5FP3 | Cell penetrant inhibitors of the JMJD2 (KDM4) and JARID1 (KDM5) families of histone lysine… | x-ray diffraction | A, B | YC8, ZN, MG, BCN, CO | 9 (best 0.72) |
| 5FP3 | Cell penetrant inhibitors of the JMJD2 (KDM4) and JARID1 (KDM5) families of histone lysine… | x-ray diffraction | A, B | — | — |
| 5OY3 | The structural basis of the histone demethylase KDM6B histone 3 lysine 27 specificity | x-ray diffraction | A | FE, ZN, AKG | 7 (best 0.76) |
| 5OY3 | The structural basis of the histone demethylase KDM6B histone 3 lysine 27 specificity | x-ray diffraction | A | FE, ZN, AKG | — |
| 6F6D | The catalytic domain of KDM6B in complex with H3(17-33)K18IA21M peptide | x-ray diffraction | A | FE, ZN, AKG | 6 (best 0.73) |
| 6F6D | The catalytic domain of KDM6B in complex with H3(17-33)K18IA21M peptide | x-ray diffraction | A | FE, ZN, AKG | — |
| O15054 | AlphaFold monomer V2.0 prediction for lysine-specific demethylase 6B (O15054) | predicted | A | — | 10 (best 0.75) |
Ligands
Experiment against prediction
- 2XUE chain A against the predicted model O15054: TM-score 0.99, RMSD 0.67 Å
- 2XUE chain A against the predicted model O15054: TM-score 0.99, RMSD 0.67 Å
- 5OY3 chain A against the predicted model O15054: TM-score 0.99, RMSD 0.75 Å
- 5OY3 chain A against the predicted model O15054: TM-score 0.99, RMSD 0.75 Å
- 6F6D chain A against the predicted model O15054: TM-score 0.99, RMSD 0.77 Å
- 6F6D chain A against the predicted model O15054: TM-score 0.99, RMSD 0.77 Å
- 4ASK chain A against the predicted model O15054: TM-score 0.99, RMSD 0.81 Å
- 4ASK chain A against the predicted model O15054: TM-score 0.99, RMSD 0.81 Å
- 5FP3 chain B against the predicted model O15054: TM-score 0.99, RMSD 0.78 Å
- 5FP3 chain B against the predicted model O15054: TM-score 0.99, RMSD 0.78 Å
Elsewhere
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