UniProt O14944
Proepiregulin (O14944)
Proepiregulin (UniProt O14944): 15 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 31 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O14944
- Protein
- Proepiregulin
- Experimental structures
- 15
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 31 · 4 records with a druggable one
Structures
16 records of O14944 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1K36 | NMR Structure of human Epiregulin | solution nmr | A | — | — |
| 1K36 | NMR structure of human epiregulin | solution nmr | A | — | — |
| 1K37 | NMR Structure of human Epiregulin | solution nmr | A | — | — |
| 1K37 | NMR structure of human epiregulin | solution nmr | A | — | — |
| 5E8D | Crystal structure of human epiregulin in complex with the Fab fragment of murine monoclonal… | x-ray diffraction | A | — | — |
| 5E8D | Crystal structure of human epiregulin in complex with the Fab fragment of murine monoclonal… | x-ray diffraction | A | — | — |
| 5WB7 | Crystal structure of the epidermal growth factor receptor extracellular region in complex with… | x-ray diffraction | E, F, G, H | NAG | 11 (best 0.80) |
| 5WB7 | Crystal structure of the epidermal growth factor receptor extracellular region in complex with… | x-ray diffraction | E, F, G, H | — | — |
| 7LEN | Crystal structure of the epidermal growth factor receptor extracellular region with R84K mutation… | x-ray diffraction | C, D | MAN | 5 (best 0.77) |
| 7LEN | Crystal structure of the epidermal growth factor receptor extracellular region with R84K mutation… | x-ray diffraction | C, D | — | — |
| 7LFR | Crystal structure of the epidermal growth factor receptor extracellular region with R84K mutation… | x-ray diffraction | C, D | — | — |
| 7LFR | Crystal structure of the epidermal growth factor receptor extracellular region with R84K mutation… | x-ray diffraction | C, D | — | — |
| 7LFS | Crystal structure of the epidermal growth factor receptor extracellular region with A265V mutation… | x-ray diffraction | E, F, G, H | — | 10 (best 0.75) |
| 7LFS | Crystal structure of the epidermal growth factor receptor extracellular region with A265V mutation… | x-ray diffraction | E, F, G, H | — | — |
| 8HGP | The EREG-bound EGFR/HER2 ectodomain complex | electron microscopy | C | — | 5 (best 0.81) |
| O14944 | AlphaFold monomer V2.0 prediction for proepiregulin (O14944) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5WB7 chain H against the predicted model O14944: TM-score 0.91, RMSD 0.69 Å
- 5WB7 chain H against the predicted model O14944: TM-score 0.91, RMSD 0.69 Å
- 5E8D chain A against the predicted model O14944: TM-score 0.90, RMSD 0.71 Å
- 5E8D chain A against the predicted model O14944: TM-score 0.90, RMSD 0.71 Å
- 7LFS chain H against the predicted model O14944: TM-score 0.90, RMSD 0.79 Å
- 7LFS chain H against the predicted model O14944: TM-score 0.90, RMSD 0.79 Å
- 7LEN chain D against the predicted model O14944: TM-score 0.89, RMSD 1.05 Å
- 7LEN chain D against the predicted model O14944: TM-score 0.89, RMSD 1.05 Å
- 7LFR chain D against the predicted model O14944: TM-score 0.89, RMSD 1.09 Å
- 7LFR chain D against the predicted model O14944: TM-score 0.89, RMSD 1.09 Å
Elsewhere
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