UniProt O14867
Transcription regulator protein BACH1 (O14867)
Transcription regulator protein BACH1 (UniProt O14867): 11 experimental structures and 1 predicted model on GenesisL1, 37 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O14867
- Protein
- Transcription regulator protein BACH1
- Experimental structures
- 11
- Predicted models
- 1
- Pockets
- 37 · 6 records with a druggable one
Structures
12 records of O14867 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2IHC | Crystal structure of the bric-a-brac (BTB) domain of human BACH1 | x-ray diffraction | A, B, C, D | — | — |
| 2IHC | Crystal structure of the bric-a-brac (btb) domain of human BACH1 | x-ray diffraction | A, B, C, D | — | — |
| 8S7D | Cryo-EM structure of SKP1-FBXO22 in complex with a BACH1 BTB dimer at 3.2A resolution | electron microscopy | A, B | — | 1 (best 0.27) |
| 8UA3 | Cryo-EM Structure of FBOX22-BACH1BTB | electron microscopy | D, E | — | 3 (best 0.38) |
| 8UA6 | Cryo-EM Structure of SCF-FBOX22-BACH1BTB | electron microscopy | D, E | — | 4 (best 0.52) |
| 8UAH | Structure of BACH1 BTB domain-bound FBXL17 ubiquitin ligase | electron microscopy | C | — | 4 (best 0.67) |
| 8UBT | Structure of SCF-FBXL17-BACH1BTB E3 ligase complex | electron microscopy | D | — | 5 (best 0.63) |
| 8UBU | Cryo-EM structure of dimeric SCF-FBXL17-BACH1BTB E3 ligase complex close conformation | electron microscopy | E, L | — | 7 (best 0.82) |
| 8UBV | Cryo-EM structure of dimeric FBXL17-BACH1BTB E3 ubiquitin ligase complex | electron microscopy | C, I | — | 9 (best 0.84) |
| 9GP5 | Homodimer of BACH1 F9A mutant BTB domain | x-ray diffraction | C, D | — | 1 (best 0.45) |
| 9GRA | Homodimer of BACH1 BTB domain in complex with 2-Methyl-2,4-pentanediol | x-ray diffraction | A, B | — | 3 (best 0.66) |
| O14867 | AlphaFold monomer V2.0 prediction for transcription regulator protein BACH1 (O14867) | predicted | A | — | — |
Experiment against prediction
- 2IHC chain B against the predicted model O14867: TM-score 0.98, RMSD 0.74 Å
- 2IHC chain B against the predicted model O14867: TM-score 0.98, RMSD 0.74 Å
- 9GP5 chain D against the predicted model O14867: TM-score 0.97, RMSD 0.74 Å
- 9GP5 chain C against the predicted model O14867: TM-score 0.97, RMSD 0.81 Å
- 2IHC chain D against the predicted model O14867: TM-score 0.96, RMSD 0.85 Å
- 2IHC chain D against the predicted model O14867: TM-score 0.96, RMSD 0.85 Å
- 2IHC chain C against the predicted model O14867: TM-score 0.96, RMSD 0.92 Å
- 2IHC chain C against the predicted model O14867: TM-score 0.96, RMSD 0.92 Å
- 2IHC chain A against the predicted model O14867: TM-score 0.96, RMSD 0.88 Å
- 2IHC chain A against the predicted model O14867: TM-score 0.96, RMSD 0.88 Å
Elsewhere
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