UniProt O14656
Torsin-1A (O14656)
Torsin-1A (UniProt O14656), EC 3.6.4.-: 5 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O14656
- Protein
- Torsin-1A
- EC
- 3.6.4.-
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 7 · 2 records with a druggable one
Structures
6 records of O14656 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5J1S | TorsinA-LULL1 complex, H. sapiens, bound to VHH-BS2 | x-ray diffraction | A | ATP, MG, CL | — |
| 5J1S | Torsina-LULL1 complex, H. sapiens, bound to vhh-BS2 | x-ray diffraction | A | — | — |
| 5J1T | TorsinAdeltaE-LULL1 complex, H. sapiens, bound to VHH-BS2 | x-ray diffraction | A | ATP, MG, CL | 5 (best 0.74) |
| 5J1T | Torsinadeltae-LULL1 complex, H. sapiens, bound to vhh-BS2 | x-ray diffraction | A | — | — |
| 6OIF | Cryo-EM structure of human TorsinA filament | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y | ATP | — |
| O14656 | AlphaFold monomer V2.0 prediction for torsin-1A (O14656) | predicted | A | — | 2 (best 0.55) |
Ligands
Experiment against prediction
- 5J1S chain A against the predicted model O14656: TM-score 0.96, RMSD 1.16 Å
- 5J1S chain A against the predicted model O14656: TM-score 0.96, RMSD 1.16 Å
- 5J1T chain A against the predicted model O14656: TM-score 0.96, RMSD 1.22 Å
- 5J1T chain A against the predicted model O14656: TM-score 0.96, RMSD 1.22 Å
- 6OIF chain A against the predicted model O14656: TM-score 0.93, RMSD 1.86 Å
Elsewhere
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