UniProt O14198
Mediator of RNA polymerase II transcription subunit 18 (O14198)
Mediator of RNA polymerase II transcription subunit 18 (UniProt O14198): 10 experimental structures and 1 predicted model on GenesisL1, 5 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O14198
- Protein
- Mediator of RNA polymerase II transcription subunit 18
- Experimental structures
- 10
- Predicted models
- 1
- Pockets
- 5 · 2 records with a druggable one
Structures
11 records of O14198 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3C0T | Structure of the Schizosaccharomyces pombe Mediator subcomplex Med8C/18 | x-ray diffraction | A | — | — |
| 3C0T | Structure of the schizosaccharomyces pombe mediator subcomplex MED8C/18 | x-ray diffraction | A | — | — |
| 4H63 | Structure of the Schizosaccharomyces pombe Mediator head module | x-ray diffraction | R | — | — |
| 4H63 | Structure of the schizosaccharomyces pombe mediator head module | x-ray diffraction | R | — | — |
| 5N9J | Core Mediator of transcriptional regulation | x-ray diffraction | X | — | — |
| 5N9J | Core mediator of transcriptional regulation | x-ray diffraction | X | — | — |
| 5U0P | Cryo-EM structure of the transcriptional Mediator | electron microscopy | R | — | 4 (best 0.74) |
| 5U0P | Cryo-EM structure of the transcriptional mediator | electron microscopy | R | — | — |
| 5U0S | Cryo-EM structure of the Mediator-RNAPII complex | electron microscopy | R | — | — |
| 5U0S | Cryo-EM structure of the mediator-rnapii complex | electron microscopy | R | — | — |
| O14198 | AlphaFold monomer V2.0 prediction for mediator of RNA polymerase II transcription subunit 18… | predicted | A | — | 1 (best 0.61) |
Experiment against prediction
- 3C0T chain A against the predicted model O14198: TM-score 0.96, RMSD 1.61 Å
- 3C0T chain A against the predicted model O14198: TM-score 0.96, RMSD 1.61 Å
- 4H63 chain R against the predicted model O14198: TM-score 0.95, RMSD 1.73 Å
- 4H63 chain R against the predicted model O14198: TM-score 0.95, RMSD 1.73 Å
- 5U0P chain R against the predicted model O14198: TM-score 0.94, RMSD 1.46 Å
- 5U0P chain R against the predicted model O14198: TM-score 0.94, RMSD 1.46 Å
- 5N9J chain X against the predicted model O14198: TM-score 0.93, RMSD 1.67 Å
- 5N9J chain X against the predicted model O14198: TM-score 0.93, RMSD 1.67 Å
- 5U0S chain R against the predicted model O14198: TM-score 0.90, RMSD 1.81 Å
- 5U0S chain R against the predicted model O14198: TM-score 0.90, RMSD 1.81 Å
Elsewhere
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