UniProt O14010
Mediator of RNA polymerase II transcription subunit 22 (O14010)
Mediator of RNA polymerase II transcription subunit 22 (UniProt O14010): 8 experimental structures and 1 predicted model on GenesisL1, 4 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O14010
- Protein
- Mediator of RNA polymerase II transcription subunit 22
- Experimental structures
- 8
- Predicted models
- 1
- Pockets
- 4 · 1 record with a druggable one
Structures
9 records of O14010 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4H63 | Structure of the Schizosaccharomyces pombe Mediator head module | x-ray diffraction | V | — | — |
| 4H63 | Structure of the schizosaccharomyces pombe mediator head module | x-ray diffraction | V | — | — |
| 5N9J | Core Mediator of transcriptional regulation | x-ray diffraction | Z | — | — |
| 5N9J | Core mediator of transcriptional regulation | x-ray diffraction | Z | — | — |
| 5U0P | Cryo-EM structure of the transcriptional Mediator | electron microscopy | V | — | 4 (best 0.80) |
| 5U0P | Cryo-EM structure of the transcriptional mediator | electron microscopy | V | — | — |
| 5U0S | Cryo-EM structure of the Mediator-RNAPII complex | electron microscopy | V | — | — |
| 5U0S | Cryo-EM structure of the mediator-rnapii complex | electron microscopy | V | — | — |
| O14010 | AlphaFold monomer V2.0 prediction for mediator of RNA polymerase II transcription subunit 22… | predicted | A | — | — |
Experiment against prediction
- 4H63 chain V against the predicted model O14010: TM-score 0.65, RMSD 2.33 Å
- 4H63 chain V against the predicted model O14010: TM-score 0.65, RMSD 2.33 Å
- 5N9J chain Z against the predicted model O14010: TM-score 0.65, RMSD 2.54 Å
- 5N9J chain Z against the predicted model O14010: TM-score 0.65, RMSD 2.54 Å
- 5U0P chain V against the predicted model O14010: TM-score 0.64, RMSD 1.97 Å
- 5U0P chain V against the predicted model O14010: TM-score 0.64, RMSD 1.97 Å
- 5U0S chain V against the predicted model O14010: TM-score 0.63, RMSD 2.57 Å
- 5U0S chain V against the predicted model O14010: TM-score 0.63, RMSD 2.57 Å
Elsewhere
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