UniProt O08785
Circadian locomoter output cycles protein kaput (O08785)
Circadian locomoter output cycles protein kaput (UniProt O08785), EC 2.3.1.48: 9 experimental structures and 1 predicted model on GenesisL1, 35 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- O08785
- Protein
- Circadian locomoter output cycles protein kaput
- EC
- 2.3.1.48
- Experimental structures
- 9
- Predicted models
- 1
- Pockets
- 35 · 5 records with a druggable one
Structures
10 records of O08785 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4F3L | Crystal Structure of the Heterodimeric CLOCK:BMAL1 Transcriptional Activator Complex | x-ray diffraction | A | — | — |
| 4F3L | Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex | x-ray diffraction | A | — | — |
| 5VJI | Crystal structure of the CLOCK Transcription Domain Exon19 in Complex with a Repressor | x-ray diffraction | A, B, D, E | — | 4 (best 0.67) |
| 5VJI | Crystal structure of the clock transcription domain EXON19 in complex with a repressor | x-ray diffraction | A, B, D, E | — | — |
| 5VJX | Crystal structure of the CLOCK Transcription Domain Exon19 in Complex with a Repressor | x-ray diffraction | B, C, E, F, H, I, K, L, N, O, S, T, V, W, Y, Z, b, c, e, f | — | 19 (best 0.82) |
| 5VJX | Crystal structure of the clock transcription domain EXON19 in complex with a repressor | x-ray diffraction | B, C, E, F, H, I, K, L, N, O, S, T, V, W, Y, Z, b, c, e, f | — | — |
| 8OSJ | Cryo-EM structure of CLOCK-BMAL1 bound to a nucleosomal E-box at position SHL-6.2 (DNA conformation… | electron microscopy | M | — | 1 (best 0.75) |
| 8OSK | Cryo-EM structure of CLOCK-BMAL1 bound to a nucleosomal E-box at position SHL+5.8 (composite map) | electron microscopy | M | — | 5 (best 0.79) |
| 8OSL | Cryo-EM structure of CLOCK-BMAL1 bound to the native Por enhancer nucleosome (map 2, additional 3D… | electron microscopy | M, O | — | 6 (best 0.81) |
| O08785 | AlphaFold monomer V2.0 prediction for circadian locomoter output cycles protein kaput (O08785) | predicted | A | — | — |
Experiment against prediction
- 4F3L chain A against the predicted model O08785: TM-score 0.99, RMSD 0.56 Å
- 4F3L chain A against the predicted model O08785: TM-score 0.99, RMSD 0.56 Å
- 5VJX chain Z against the predicted model O08785: TM-score 0.94, RMSD 0.43 Å
- 5VJX chain Z against the predicted model O08785: TM-score 0.94, RMSD 0.43 Å
- 5VJX chain c against the predicted model O08785: TM-score 0.92, RMSD 0.54 Å
- 5VJX chain c against the predicted model O08785: TM-score 0.92, RMSD 0.54 Å
- 5VJX chain f against the predicted model O08785: TM-score 0.90, RMSD 0.79 Å
- 5VJX chain f against the predicted model O08785: TM-score 0.90, RMSD 0.79 Å
- 5VJX chain T against the predicted model O08785: TM-score 0.89, RMSD 1.38 Å
- 5VJX chain T against the predicted model O08785: TM-score 0.89, RMSD 1.38 Å
Elsewhere
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