UniProt O08734
Bcl-2 homologous antagonist/killer (O08734)
Bcl-2 homologous antagonist/killer (UniProt O08734): 6 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 4 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O08734
- Protein
- Bcl-2 homologous antagonist/killer
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 4 · 1 record with a druggable one
Structures
7 records of O08734 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2VOH | Structure of mouse A1 bound to the Bak BH3-domain | x-ray diffraction | B | — | — |
| 2VOH | Structure of mouse A1 bound to the bak BH3-domain | x-ray diffraction | B | — | — |
| 5KTG | Crystal structure of mouse Bak BH3-in-groove homodimer (GFP) | x-ray diffraction | A, B | — | — |
| 5KTG | Crystal structure of mouse bak BH3-in-groove homodimer (GFP) | x-ray diffraction | A, B | CR2 | — |
| 6MCY | Crystal structure of mouse Bak | x-ray diffraction | A, B, C, D | — | 4 (best 0.80) |
| 6MCY | Crystal structure of mouse bak | x-ray diffraction | A, B, C, D | — | — |
| O08734 | AlphaFold monomer V2.0 prediction for BCL-2 homologous ANTAGONIST/KILLER (O08734) | predicted | A | — | — |
Ligands
- CR2 · {(4Z)-2-(aminomethyl)-4-[(4-hydroxyphenyl)methylidene]-5-oxo-4,5-dihydro-1H-imidazol-1-yl}acetic acid · in 1 record
Experiment against prediction
- 5KTG chain B against the predicted model P42212: TM-score 0.75, RMSD 0.77 Å
- 5KTG chain B against the predicted model P42212: TM-score 0.75, RMSD 0.77 Å
- 5KTG chain A against the predicted model P42212: TM-score 0.75, RMSD 0.97 Å
- 5KTG chain A against the predicted model P42212: TM-score 0.75, RMSD 0.97 Å
- 6MCY chain B against the predicted model O08734: TM-score 0.93, RMSD 1.56 Å
- 6MCY chain B against the predicted model O08734: TM-score 0.93, RMSD 1.56 Å
- 6MCY chain D against the predicted model O08734: TM-score 0.93, RMSD 1.48 Å
- 6MCY chain D against the predicted model O08734: TM-score 0.93, RMSD 1.48 Å
- 6MCY chain A against the predicted model O08734: TM-score 0.92, RMSD 1.60 Å
- 6MCY chain A against the predicted model O08734: TM-score 0.92, RMSD 1.60 Å
Elsewhere
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