UniProt O08679
SERINE/THREONINE-protein kinase MARK2 (O08679)
SERINE/THREONINE-protein kinase MARK2 (UniProt O08679): 9 experimental structures and 1 predicted model on GenesisL1, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O08679
- Protein
- SERINE/THREONINE-protein kinase MARK2
- Experimental structures
- 9
- Predicted models
- 1
- Pockets
- 7 · 1 record with a druggable one
Structures
10 records of O08679 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1ZMU | Catalytic and ubiqutin-associated domains of MARK2/PAR-1: Wild type | x-ray diffraction | A, B | — | — |
| 1ZMU | Catalytic and ubiqutin-associated domains of MARK2/PAR-1: wild type | x-ray diffraction | A, B | — | — |
| 1ZMV | Catalytic and ubiqutin-associated domains of MARK2/PAR-1: K82R mutant | x-ray diffraction | A, B | — | — |
| 1ZMV | Catalytic and ubiqutin-associated domains of MARK2/PAR-1: K82R mutant | x-ray diffraction | A, B | — | — |
| 1ZMW | Catalytic and ubiqutin-associated domains of MARK2/PAR-1: T208A/S212A inactive double mutant | x-ray diffraction | A, B | — | — |
| 1ZMW | Catalytic and ubiqutin-associated domains of MARK2/PAR-1: T208A/S212A inactive double mutant | x-ray diffraction | A, B | — | — |
| 2R0I | Crystal structure of a kinase MARK2/Par-1 mutant | x-ray diffraction | A, B | — | — |
| 2R0I | Crystal structure of a kinase MARK2/PAR-1 mutant | x-ray diffraction | A, B | — | — |
| 2WZJ | Catalytic and uba domain of kinase MARK2/(PAR-1) K82R, T208E double mutant | x-ray diffraction | A, B, C, D, E, F | — | — |
| O08679 | AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase MARK2 (O08679) | predicted | A | — | 7 (best 0.79) |
Experiment against prediction
- 1ZMU chain B against the predicted model O08679: TM-score 0.98, RMSD 1.03 Å
- 1ZMU chain B against the predicted model O08679: TM-score 0.98, RMSD 1.03 Å
- 1ZMV chain B against the predicted model O08679: TM-score 0.98, RMSD 1.12 Å
- 1ZMV chain B against the predicted model O08679: TM-score 0.98, RMSD 1.12 Å
- 1ZMU chain A against the predicted model O08679: TM-score 0.97, RMSD 1.14 Å
- 1ZMU chain A against the predicted model O08679: TM-score 0.97, RMSD 1.14 Å
- 2R0I chain A against the predicted model O08679: TM-score 0.97, RMSD 1.19 Å
- 2R0I chain A against the predicted model O08679: TM-score 0.97, RMSD 1.19 Å
- 1ZMV chain A against the predicted model O08679: TM-score 0.97, RMSD 1.22 Å
- 1ZMV chain A against the predicted model O08679: TM-score 0.97, RMSD 1.22 Å
Elsewhere
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