UniProt O07550
Probable multidrug resistance ABC transporter ATP-binding/permease protein YheI (O07550)
Probable multidrug resistance ABC transporter ATP-binding/permease protein YheI (UniProt O07550), EC 7.6.2.-: 5 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 50 pockets. Binding sites, druggability…
- UniProt
- O07550
- Protein
- Probable multidrug resistance ABC transporter ATP-binding/permease protein YheI
- EC
- 7.6.2.-
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 50 · 4 records with a druggable one
Structures
6 records of O07550 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7M33 | The structure of bacillus subtilis bmrcd in the inward-facing conformation bound to hoechst-33342… | electron microscopy | C | ATP, HT1 | — |
| 8FHK | Heterodimeric ABC transporter BmrCD in the occluded conformation bound to ATP: BmrCD_OC-ATP | electron microscopy | C | ATP, POV, MG | 14 (best 0.89) |
| 8FMV | Heterodimeric ABC transporter BmrCD in the inward-facing conformation bound to substrate and ATP… | electron microscopy | C | POV, ATP, HT1 | 8 (best 0.81) |
| 8T1P | Heterodimeric ABC transporter BmrCD in the occluded conformation bound to ADPVi: BmrCD_OC-ADPVi | electron microscopy | C | ATP, MG, POV, AOV | 14 (best 0.89) |
| 8T3K | Heterodimeric ABC transporter BmrCD in the inward-facing conformation bound to ATP: BmrCD_IF-ATP2 | electron microscopy | C | POV, ATP | 11 (best 0.82) |
| O07550 | AlphaFold monomer V2.0 prediction for probable multidrug resistance ABC transporter… | predicted | A | — | 3 (best 0.47) |
Ligands
- ATP · Adenosine-5'-triphosphate · in 5 records
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · in 4 records
- HT1 · 2'-(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bi-benzimidazole · in 2 records
- MG · Magnesium ion · in 2 records
- AOV · Adp orthovanadate · in 1 record
Experiment against prediction
- 8FMV chain C against the predicted model O07550: TM-score 0.93, RMSD 2.36 Å
- 7M33 chain C against the predicted model O07550: TM-score 0.93, RMSD 2.34 Å
- 8T3K chain C against the predicted model O07550: TM-score 0.93, RMSD 2.36 Å
- 8T1P chain C against the predicted model O07550: TM-score 0.86, RMSD 4.09 Å
- 8FHK chain C against the predicted model O07550: TM-score 0.85, RMSD 4.16 Å
Elsewhere
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