UniProt O07431
Probable O-methyltransferase (O07431)
Probable O-methyltransferase (UniProt O07431): 4 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 28 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O07431
- Protein
- Probable O-methyltransferase
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 28 · 2 records with a druggable one
Structures
5 records of O07431 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6JCL | Crystal structure of cofactor-bound Rv0187 from MTB | x-ray diffraction | A, B, C, D, G, H, E, F | SAH, SR, NA | 20 (best 0.84) |
| 6JCL | Crystal structure of cofactor-bound RV0187 from mtb | x-ray diffraction | A, B, C, D, G, H, E, F | SR, NA | — |
| 6JCM | Crystal structure of ligand-free Rv0187. | x-ray diffraction | A, B, C, D | — | 8 (best 0.71) |
| 6JCM | Crystal structure of ligand-free RV0187. | x-ray diffraction | A, B, C, D | — | — |
| O07431 | AlphaFold monomer V2.0 prediction for catechol O-methyltransferase (O07431) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6JCL chain C against the predicted model O07431: TM-score 0.99, RMSD 0.39 Å
- 6JCL chain F against the predicted model O07431: TM-score 0.99, RMSD 0.47 Å
- 6JCL chain C against the predicted model O07431: TM-score 0.99, RMSD 0.39 Å
- 6JCL chain D against the predicted model O07431: TM-score 0.99, RMSD 0.59 Å
- 6JCL chain F against the predicted model O07431: TM-score 0.99, RMSD 0.47 Å
- 6JCM chain A against the predicted model O07431: TM-score 0.99, RMSD 0.66 Å
- 6JCM chain A against the predicted model O07431: TM-score 0.99, RMSD 0.66 Å
- 6JCM chain C against the predicted model O07431: TM-score 0.99, RMSD 0.68 Å
- 6JCM chain C against the predicted model O07431: TM-score 0.99, RMSD 0.68 Å
- 6JCM chain D against the predicted model O07431: TM-score 0.99, RMSD 0.69 Å
Elsewhere
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