UniProt O06967
Multidrug resistance ABC transporter ATP-binding/permease protein BmrA (O06967)
Multidrug resistance ABC transporter ATP-binding/permease protein BmrA (UniProt O06967), EC 7.6.2.-: 10 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 159 pockets. Binding sites, druggability and…
- UniProt
- O06967
- Protein
- Multidrug resistance ABC transporter ATP-binding/permease protein BmrA
- EC
- 7.6.2.-
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 159 · 9 records with a druggable one
Structures
11 records of O06967 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7BG4 | Multidrug resistance transporter BmrA mutant E504A bound with ATP, Mg, and Rhodamine 6G solved by… | electron microscopy | A, B | ATP, MG, RHQ | 16 (best 0.83) |
| 7OW8 | CryoEM structure of the ABC transporter BmrA E504A mutant in complex with ATP-Mg | electron microscopy | A, B | ATP, MG | 14 (best 0.82) |
| 7OW8 | Cryoem structure of the ABC transporter bmra E504A mutant in complex with ATP-mg | electron microscopy | A, B | ATP, MG | — |
| 8CHB | Inward-facing conformation of the ABC transporter BmrA C436S/A582C cross-linked mutant | electron microscopy | A, B | — | 17 (best 0.76) |
| 8QOE | Inward-facing conformation of the ABC transporter BmrA | electron microscopy | B, A | — | 18 (best 0.78) |
| 8RF1 | BmrA E504-R6G | electron microscopy | A, B | RHQ | 20 (best 0.79) |
| 8RG7 | BmrA E504-R6G-25uMATP-Mg | electron microscopy | A, B | RHQ | 18 (best 0.73) |
| 8RGA | BmrA E504-25uMATPMg | electron microscopy | A, B | — | 19 (best 0.78) |
| 8RGN | BmrA E504-R6G-70uMATPMg | electron microscopy | A, B | RHQ, ATP, MG | 17 (best 0.87) |
| 8RIA | BmrA E504-100uMATPMg-IF | electron microscopy | A, B | — | 20 (best 0.81) |
| O06967 | AlphaFold monomer V2.0 prediction for multidrug resistance ABC transporter ATP-BINDING/PERMEASE… | predicted | A | — | — |
Ligands
Experiment against prediction
- 8QOE chain A against the predicted model O06967: TM-score 0.85, RMSD 3.93 Å
- 8QOE chain B against the predicted model O06967: TM-score 0.85, RMSD 3.93 Å
- 8CHB chain A against the predicted model O06967: TM-score 0.84, RMSD 4.20 Å
- 8CHB chain B against the predicted model O06967: TM-score 0.84, RMSD 4.20 Å
- 8RG7 chain A against the predicted model O06967: TM-score 0.83, RMSD 3.74 Å
- 8RGA chain B against the predicted model O06967: TM-score 0.83, RMSD 3.80 Å
- 8RGA chain A against the predicted model O06967: TM-score 0.83, RMSD 3.72 Å
- 8RIA chain A against the predicted model O06967: TM-score 0.83, RMSD 3.69 Å
- 8RIA chain B against the predicted model O06967: TM-score 0.83, RMSD 3.79 Å
- 8RG7 chain B against the predicted model O06967: TM-score 0.82, RMSD 3.96 Å
Elsewhere
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