UniProt O06291
Probable serine protease HtrA1 (O06291)
Probable serine protease HtrA1 (UniProt O06291), EC 3.4.21.107: 4 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 4 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- O06291
- Protein
- Probable serine protease HtrA1
- EC
- 3.4.21.107
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 4 · 0 records with a druggable one
Structures
5 records of O06291 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6IEO | Crystal structure of mycobacterium tuberculosis HTRA1 (RV1223) in regulated conformation | x-ray diffraction | A | PMS | — |
| 7VYZ | Structure of the M. tuberculosis HtrA S367A mutant | x-ray diffraction | A | — | — |
| 7W22 | Structure of the M. tuberculosis HtrA K436A mutant | x-ray diffraction | A | — | 2 (best 0.49) |
| 7W4V | Structure of the M. tuberculosis HtrA S413A mutant at room temperature | x-ray diffraction | A | — | 2 (best 0.43) |
| O06291 | AlphaFold monomer V2.0 prediction for probable serine protease HTRA1 (O06291) | predicted | A | — | — |
Ligands
- PMS · phenylmethanesulfonic acid · in 1 record
Experiment against prediction
- 7W4V chain A against the predicted model O06291: TM-score 0.97, RMSD 1.22 Å
- 7VYZ chain A against the predicted model O06291: TM-score 0.96, RMSD 1.23 Å
- 7W22 chain A against the predicted model O06291: TM-score 0.96, RMSD 1.25 Å
- 6IEO chain A against the predicted model O06291: TM-score 0.96, RMSD 1.27 Å
Elsewhere
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