UniProt O05701
Dihydropteroate synthase (O05701)
Dihydropteroate synthase (UniProt O05701), EC 2.5.1.15: 8 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 14 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O05701
- Protein
- Dihydropteroate synthase
- EC
- 2.5.1.15
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 14 · 2 records with a druggable one
Structures
9 records of O05701 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AD1 | Dihydropteroate synthetase (apo form) from staphylococcus aureus | x-ray diffraction | A, B | — | — |
| 1AD1 | Dihydropteroate synthetase (apo form) from staphylococcus aureus | x-ray diffraction | A, B | — | — |
| 1AD4 | Dihydropteroate synthetase complexed with oh-CH2-pterin-pyrophosphate from staphylococcus aureus | x-ray diffraction | A, B | — | — |
| 1AD4 | Dihydropteroate synthetase complexed with oh-CH2-pterin- pyrophosphate from staphylococcus aureus | x-ray diffraction | A, B | — | — |
| 6CLU | Staphylococcus aureus Dihydropteroate Synthase (saDHPS) F17L E208K double mutant structure | x-ray diffraction | A, B, C, D | — | 7 (best 0.62) |
| 6CLU | Staphylococcus aureus dihydropteroate synthase (sadhps) F17L E208K double mutant structure | x-ray diffraction | A, B, C, D | — | — |
| 6CLV | Staphylococcus aureus Dihydropteroate Synthase (saDHPS) F17L E208K double mutant structure | x-ray diffraction | A, B, C, D | 6MB | 7 (best 0.77) |
| 6CLV | Staphylococcus aureus dihydropteroate synthase (sadhps) F17L E208K double mutant structure | x-ray diffraction | A, B, C, D | 6MB | — |
| O05701 | AlphaFold monomer V2.0 prediction for dihydropteroate synthase (O05701) | predicted | A | — | — |
Ligands
- 6MB · 4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl) methyl]amino}-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzene-1-sulfonamide · in 2 records
Experiment against prediction
- 6CLU chain B against the predicted model O05701: TM-score 0.99, RMSD 0.53 Å
- 6CLU chain B against the predicted model O05701: TM-score 0.99, RMSD 0.53 Å
- 6CLV chain D against the predicted model O05701: TM-score 0.99, RMSD 0.71 Å
- 6CLV chain D against the predicted model O05701: TM-score 0.99, RMSD 0.71 Å
- 1AD1 chain B against the predicted model O05701: TM-score 0.98, RMSD 1.04 Å
- 1AD1 chain B against the predicted model O05701: TM-score 0.98, RMSD 1.04 Å
- 1AD4 chain B against the predicted model O05701: TM-score 0.98, RMSD 1.02 Å
- 1AD4 chain B against the predicted model O05701: TM-score 0.98, RMSD 1.02 Å
- 1AD4 chain A against the predicted model O05701: TM-score 0.98, RMSD 0.92 Å
- 1AD4 chain A against the predicted model O05701: TM-score 0.98, RMSD 0.92 Å
Elsewhere
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