UniProt O00763
Acetyl-CoA carboxylase 2 (O00763)
Acetyl-CoA carboxylase 2 (UniProt O00763), EC 6.3.4.14, 6.4.1.2: 16 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 126 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O00763
- Protein
- Acetyl-CoA carboxylase 2
- EC
- 6.3.4.14, 6.4.1.2
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 126 · 14 records with a druggable one
Structures
17 records of O00763 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2KCC | Solution Structure of biotinoyl domain from human acetyl-CoA carboxylase 2 | solution nmr | A | — | — |
| 2KCC | Solution structure of biotinoyl domain from human acetyl-CoA carboxylase 2 | solution nmr | A | — | — |
| 3FF6 | Human ACC2 CT domain with CP-640186 | x-ray diffraction | A, B, C, D | RCP | 20 (best 0.82) |
| 3FF6 | Human ACC2 ct domain with cp-640186 | x-ray diffraction | A, B, C, D | RCP | 20 (best 0.82) |
| 3GID | The biotin carboxylase (BC) domain of human Acetyl-CoA Carboxylase 2 (ACC2) in complex with… | x-ray diffraction | A, B | S1A | 13 (best 0.79) |
| 3GID | The biotin carboxylase (bc) domain of human acetyl-CoA carboxylase 2 (ACC2) in complex with… | x-ray diffraction | A, B | S1A | 13 (best 0.79) |
| 3GLK | The biotin carboxylase (BC) domain of human Acetyl-CoA Carboxylase 2 (ACC2) | x-ray diffraction | A | — | 6 (best 0.61) |
| 3GLK | The biotin carboxylase (bc) domain of human acetyl-CoA carboxylase 2 (ACC2) | x-ray diffraction | A | — | 6 (best 0.61) |
| 3JRW | Phosphorylated BC domain of ACC2 | x-ray diffraction | A | — | 4 (best 0.69) |
| 3JRW | Phosphorylated bc domain of ACC2 | x-ray diffraction | A | — | 4 (best 0.69) |
| 3JRX | Crystal structure of the BC domain of ACC2 in complex with soraphen A | x-ray diffraction | A | S1A | 4 (best 0.73) |
| 3JRX | Crystal structure of the bc domain of ACC2 in complex with soraphen a | x-ray diffraction | A | S1A | 4 (best 0.73) |
| 4HQ6 | BC domain in the presence of citrate | x-ray diffraction | A | — | 4 (best 0.70) |
| 4HQ6 | Bc domain in the presence of citrate | x-ray diffraction | A | — | 4 (best 0.70) |
| 5KKN | Crystal structure of human ACC2 BC domain in complex with ND-646, the primary amide of ND-630 | x-ray diffraction | B, C | 6U3 | 12 (best 0.74) |
| 5KKN | Crystal structure of human ACC2 bc domain in complex with nd-646, the primary amide of nd-630 | x-ray diffraction | B, C | 6U3 | 12 (best 0.74) |
| O00763 | AlphaFold monomer V2.0 prediction for acetyl-CoA carboxylase 2 (O00763) | predicted | A | — | — |
Ligands
- S1A · Soraphen A · in 4 records
- 6U3 · 2-[1-[(2~{R})-2-(2-methoxyphenyl)-2-(oxan-4-yloxy) ethyl]-5-methyl-6-(1,3-oxazol-2-yl)-2,4-bis(oxidanylidene)thieno[2,3-d]pyrimidin-3-yl]-2-methyl-propanamide · in 2 records
- RCP · (3R)-1'-(9-anthrylcarbonyl)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidine · in 2 records
Experiment against prediction
- 3FF6 chain D against the predicted model O00763: TM-score 0.98, RMSD 1.27 Å
- 3FF6 chain D against the predicted model O00763: TM-score 0.98, RMSD 1.27 Å
- 3FF6 chain B against the predicted model O00763: TM-score 0.98, RMSD 1.30 Å
- 3FF6 chain B against the predicted model O00763: TM-score 0.98, RMSD 1.30 Å
- 3FF6 chain A against the predicted model O00763: TM-score 0.98, RMSD 1.51 Å
- 3FF6 chain A against the predicted model O00763: TM-score 0.98, RMSD 1.51 Å
- 3FF6 chain C against the predicted model O00763: TM-score 0.97, RMSD 1.55 Å
- 3FF6 chain C against the predicted model O00763: TM-score 0.97, RMSD 1.55 Å
- 5KKN chain C against the predicted model O00763: TM-score 0.95, RMSD 1.96 Å
- 5KKN chain C against the predicted model O00763: TM-score 0.95, RMSD 1.96 Å
Elsewhere
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