UniProt O00459
Phosphatidylinositol 3-kinase regulatory subunit beta (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (UniProt O00459): 16 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 19 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O00459
- Protein
- Phosphatidylinositol 3-kinase regulatory subunit beta
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 19 · 5 records with a druggable one
Structures
17 records of O00459 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2KT1 | Solution NMR Structure of the SH3 Domain from the p85beta subunit of Phosphatidylinositol 3-kinase… | solution nmr | A | — | — |
| 2KT1 | Solution NMR structure of the SH3 domain from the P85BETA subunit of phosphatidylinositol 3-kinase… | solution nmr | A | — | — |
| 2XS6 | Crystal structure of the rhogap domain of human PIK3R2 | x-ray diffraction | A | CL | 1 (best 0.41) |
| 2XS6 | Crystal structure of the rhogap domain of human PIK3R2 | x-ray diffraction | A | — | — |
| 3MTT | Crystal structure of iSH2 domain of human p85beta, Northeast Structural Genomics Consortium Target… | x-ray diffraction | A | — | — |
| 3MTT | Crystal structure of ISH2 domain of human P85BETA, northeast structural genomics consortium target… | x-ray diffraction | A | — | — |
| 3O5Z | Crystal structure of the SH3 domain from p85beta subunit of phosphoinositide 3-kinase (PI3K) | x-ray diffraction | A, B | CL | 1 (best 0.52) |
| 3O5Z | Crystal structure of the SH3 domain from P85BETA subunit of phosphoinositide 3-kinase (PI3K) | x-ray diffraction | A, B | — | — |
| 6OX7 | The complex of 1918 NS1-ED and the iSH2 domain of the human p85beta subunit of PI3K | x-ray diffraction | C, D | — | 3 (best 0.86) |
| 6OX7 | The complex of 1918 NS1-ed and the ISH2 domain of the human P85BETA subunit of PI3K | x-ray diffraction | C, D | — | — |
| 6U28 | Crystal structure of 1918 NS1-ED W187A in complex with the p85-beta-iSH2 domain of human PI3K | x-ray diffraction | C, D | — | 3 (best 0.86) |
| 6U28 | Crystal structure of 1918 NS1-ed W187A in complex with the P85-beta- ISH2 domain of human PI3K | x-ray diffraction | C, D | — | — |
| 7RCH | Crystal structure of NS1-ED of Vietnam influenza A virus in complex with the p85-beta-iSH2 domain… | x-ray diffraction | C, D | — | 3 (best 0.86) |
| 7RCH | Crystal structure of NS1-ed of vietnam influenza a virus in complex with the P85-beta-ISH2 domain… | x-ray diffraction | C, D | — | — |
| 7RNU | nSH2 domain of p85-beta subunit of phosphatidylinositol 3-kinase in complex with an actin peptide… | x-ray diffraction | A, C, E, G | — | 4 (best 0.70) |
| 7RNU | NSH2 domain of P85-beta subunit of phosphatidylinositol 3-kinase in complex with an actin peptide… | x-ray diffraction | A, C, E, G | — | — |
| O00459 | AlphaFold monomer V2.0 prediction for phosphatidylinositol 3-kinase regulatory subunit beta (O00459) | predicted | A | — | 4 (best 0.50) |
Ligands
- CL · Chloride ion · in 2 records
Experiment against prediction
- 7RNU chain A against the predicted model O00459: TM-score 0.98, RMSD 0.57 Å
- 7RNU chain A against the predicted model O00459: TM-score 0.98, RMSD 0.57 Å
- 7RNU chain E against the predicted model O00459: TM-score 0.98, RMSD 0.57 Å
- 7RNU chain E against the predicted model O00459: TM-score 0.98, RMSD 0.57 Å
- 7RNU chain G against the predicted model O00459: TM-score 0.98, RMSD 0.61 Å
- 7RNU chain G against the predicted model O00459: TM-score 0.98, RMSD 0.61 Å
- 3O5Z chain B against the predicted model O00459: TM-score 0.98, RMSD 0.48 Å
- 3O5Z chain B against the predicted model O00459: TM-score 0.98, RMSD 0.48 Å
- 2XS6 chain A against the predicted model O00459: TM-score 0.97, RMSD 0.89 Å
- 2XS6 chain A against the predicted model O00459: TM-score 0.97, RMSD 0.89 Å
Elsewhere
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