UniProt O00370
LINE-1 retrotransposable element ORF2 protein (O00370)
LINE-1 retrotransposable element ORF2 protein (UniProt O00370), EC 2.7.7.49, 3.1.21.-: 9 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 97 pockets. Binding sites, druggability and experiment against…
- UniProt
- O00370
- Protein
- LINE-1 retrotransposable element ORF2 protein
- EC
- 2.7.7.49, 3.1.21.-
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 97 · 10 records with a druggable one
Structures
10 records of O00370 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7N8K | LINE-1 endonuclease domain complex with Mg | x-ray diffraction | A, B | MG, SO4 | 5 (best 0.57) |
| 7N8K | Line-1 endonuclease domain complex with mg | x-ray diffraction | A, B | MG, SO4 | 5 (best 0.57) |
| 7N8S | LINE-1 endonuclease domain complex with DNA | x-ray diffraction | A | — | 5 (best 0.66) |
| 7N8S | Line-1 endonuclease domain complex with DNA | x-ray diffraction | A | — | 5 (best 0.66) |
| 7N94 | LINE-1 endonuclease domain complex with DNA | x-ray diffraction | A, B | — | 11 (best 0.71) |
| 7N94 | Line-1 endonuclease domain complex with DNA | x-ray diffraction | A, B | — | 10 (best 0.71) |
| 8SXT | Structure of LINE-1 ORF2p with template:primer hybrid | electron microscopy | A | TTP, MG | 8 (best 0.70) |
| 8SXU | Structure of LINE-1 ORF2p with an oligo(A) template | electron microscopy | A | — | 16 (best 0.77) |
| 8UW3 | Human LINE-1 retrotransposon ORF2 protein engaged with template RNA in elongation state | electron microscopy | A | TTP | 17 (best 0.80) |
| O00370 | AlphaFold monomer V2.0 prediction for line-1 retrotransposable element ORF2 protein (O00370) | predicted | A | — | 15 (best 0.66) |
Ligands
Experiment against prediction
- 7N8K chain A against the predicted model O00370: TM-score 0.99, RMSD 0.49 Å
- 7N8K chain A against the predicted model O00370: TM-score 0.99, RMSD 0.49 Å
- 7N8K chain B against the predicted model O00370: TM-score 0.99, RMSD 0.52 Å
- 7N8K chain B against the predicted model O00370: TM-score 0.99, RMSD 0.52 Å
- 7N94 chain A against the predicted model O00370: TM-score 0.99, RMSD 0.57 Å
- 7N94 chain A against the predicted model O00370: TM-score 0.99, RMSD 0.57 Å
- 7N8S chain A against the predicted model O00370: TM-score 0.99, RMSD 0.63 Å
- 7N8S chain A against the predicted model O00370: TM-score 0.99, RMSD 0.63 Å
- 8SXU chain A against the predicted model O00370: TM-score 0.98, RMSD 1.34 Å
- 8SXT chain A against the predicted model O00370: TM-score 0.98, RMSD 1.41 Å
Elsewhere
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