UniProt O00330
Pyruvate dehydrogenase protein X component (O00330)
Pyruvate dehydrogenase protein X component (UniProt O00330): 10 experimental structures and 1 predicted model on GenesisL1, 32 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O00330
- Protein
- Pyruvate dehydrogenase protein X component
- Experimental structures
- 10
- Predicted models
- 1
- Pockets
- 32 · 7 records with a druggable one
Structures
11 records of O00330 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1ZY8 | The crystal structure of dihydrolipoamide dehydrogenase and dihydrolipoamide dehydrogenase-binding… | x-ray diffraction | K, L, M, N, O | — | 7 (best 0.81) |
| 1ZY8 | The crystal structure of dihydrolipoamide dehydrogenase and dihydrolipoamide dehydrogenase-binding… | x-ray diffraction | K, L, M, N, O | — | 7 (best 0.81) |
| 2DNC | Solution Structure of RSGI RUH-054, a lipoyl domain from human 2-oxoacid dehydrogenase | solution nmr | A | — | — |
| 2DNC | Solution structure of rsgi ruh-054, a lipoyl domain from human 2- oxoacid dehydrogenase | solution nmr | A | — | — |
| 2F5Z | Crystal Structure of Human Dihydrolipoamide Dehydrogenase (E3) Complexed to the E3-Binding Domain… | x-ray diffraction | K, L, M, N, O | — | 6 (best 0.81) |
| 2F5Z | Crystal structure of human dihydrolipoamide dehydrogenase (E3) complexed to the E3-binding domain… | x-ray diffraction | K, L, M, N, O | — | 6 (best 0.81) |
| 2F60 | Crystal Structure of the Dihydrolipoamide Dehydrogenase (E3)-Binding Domain of Human E3-Binding… | x-ray diffraction | K | — | — |
| 2F60 | Crystal structure of the dihydrolipoamide dehydrogenase (E3)-binding domain of human E3-binding… | x-ray diffraction | K | — | — |
| 6H60 | pseudo-atomic structural model of the E3BP component of the human pyruvate dehydrogenase… | electron microscopy | A | — | 2 (best 0.67) |
| 6H60 | Pseudo-atomic structural model of the E3BP component of the human pyruvate dehydrogenase… | electron microscopy | A | — | 2 (best 0.67) |
| O00330 | AlphaFold monomer V2.0 prediction for pyruvate dehydrogenase protein X component, mitochondrial… | predicted | A | — | 2 (best 0.68) |
Experiment against prediction
- 2F5Z chain K against the predicted model O00330: TM-score 0.94, RMSD 0.56 Å
- 2F5Z chain K against the predicted model O00330: TM-score 0.94, RMSD 0.56 Å
- 6H60 chain A against the predicted model O00330: TM-score 0.93, RMSD 1.93 Å
- 6H60 chain A against the predicted model O00330: TM-score 0.93, RMSD 1.93 Å
- 1ZY8 chain K against the predicted model O00330: TM-score 0.91, RMSD 0.67 Å
- 1ZY8 chain K against the predicted model O00330: TM-score 0.91, RMSD 0.67 Å
- 2DNC chain A against the predicted model O00330: TM-score 0.85, RMSD 1.45 Å
- 2DNC chain A against the predicted model O00330: TM-score 0.85, RMSD 1.45 Å
- 2F60 chain K against the predicted model O00330: TM-score 0.74, RMSD 2.01 Å
- 2F60 chain K against the predicted model O00330: TM-score 0.74, RMSD 2.01 Å
Elsewhere
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