UniProt O00303
Eukaryotic translation initiation factor 3 subunit F (O00303)
Eukaryotic translation initiation factor 3 subunit F (UniProt O00303), EC 3.4.19.12: 9 experimental structures and 1 predicted model on GenesisL1, 15 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O00303
- Protein
- Eukaryotic translation initiation factor 3 subunit F
- EC
- 3.4.19.12
- Experimental structures
- 9
- Predicted models
- 1
- Pockets
- 15 · 7 records with a druggable one
Structures
10 records of O00303 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6YBD | Structure of a human 48S translational initiation complex - EIF3 | electron microscopy | 4 | — | — |
| 6ZON | SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 1 | electron microscopy | F | — | 3 (best 0.83) |
| 7A09 | Structure of a human ABCE1-bound 43S pre-initiation complex - State III | electron microscopy | F | — | — |
| 7QP6 | Structure of the human 48S initiation complex in open state (h48S AUG open) | electron microscopy | 4 | — | 1 (best 0.86) |
| 7QP7 | Structure of the human 48S initiation complex in closed state (h48S AUG closed) | electron microscopy | 4 | — | 1 (best 0.84) |
| 8PJ1 | Structure of human 48S translation initiation complex in open codon scanning state (48S-1) | electron microscopy | 4 | — | 2 (best 0.85) |
| 8PJ6 | Structure of human 48S translation initiation complex with initiator tRNA, eIF1A and eIF3… | electron microscopy | 4 | — | 2 (best 0.85) |
| 8PPL | MERS-CoV Nsp1 bound to the human 43S pre-initiation complex | electron microscopy | I4 | — | 1 (best 0.86) |
| 8RG0 | Structure of human eIF3 core from closed 48S translation initiation complex | electron microscopy | 4 | — | 5 (best 0.87) |
| O00303 | AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 3 subunit F (O00303) | predicted | A | — | — |
Experiment against prediction
- 8PPL chain I4 against the predicted model O00303: TM-score 0.97, RMSD 1.12 Å
- 6ZON chain F against the predicted model O00303: TM-score 0.96, RMSD 1.33 Å
- 7A09 chain F against the predicted model O00303: TM-score 0.95, RMSD 1.43 Å
- 8RG0 chain 4 against the predicted model O00303: TM-score 0.92, RMSD 1.76 Å
- 8PJ1 chain 4 against the predicted model O00303: TM-score 0.91, RMSD 1.96 Å
- 6YBD chain 4 against the predicted model O00303: TM-score 0.89, RMSD 2.22 Å
- 7QP6 chain 4 against the predicted model O00303: TM-score 0.86, RMSD 2.42 Å
- 7QP7 chain 4 against the predicted model O00303: TM-score 0.85, RMSD 2.56 Å
- 8PJ6 chain 4 against the predicted model O00303: TM-score 0.83, RMSD 2.89 Å
Elsewhere
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