UniProt O00257
E3 SUMO-protein ligase CBX4 (O00257)
E3 SUMO-protein ligase CBX4 (UniProt O00257), EC 6.3.2.-: 6 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 3 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O00257
- Protein
- E3 SUMO-protein ligase CBX4
- EC
- 6.3.2.-
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 3 · 2 records with a druggable one
Structures
7 records of O00257 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2K28 | Solution NMR structure of the chromo domain of the chromobox protein homolog 4 | solution nmr | A | — | — |
| 2K28 | Solution NMR structure of the chromo domain of the chromobox protein homolog 4 | solution nmr | A | — | — |
| 3I8Z | Crystal structure of human chromobox homolog 4 (CBX4) | x-ray diffraction | A | — | — |
| 3I8Z | Crystal structure of human chromobox homolog 4 (CBX4) | x-ray diffraction | A | — | — |
| 5EPL | Crystal Structure of chromodomain of CBX4 in complex with inhibitor UNC3866 | x-ray diffraction | A, B | UNX | 1 (best 0.51) |
| 5EPL | Crystal structure of chromodomain of CBX4 in complex with inhibitor UNC3866 | x-ray diffraction | A, B | 5R0, UNX | 1 (best 0.51) |
| O00257 | AlphaFold monomer V2.0 prediction for E3 sumo-protein ligase CBX4 (O00257) | predicted | A | — | 1 (best 0.39) |
Ligands
Experiment against prediction
- 5EPL chain B against the predicted model O00257: TM-score 0.91, RMSD 0.66 Å
- 5EPL chain B against the predicted model O00257: TM-score 0.91, RMSD 0.66 Å
- 5EPL chain A against the predicted model O00257: TM-score 0.84, RMSD 2.00 Å
- 5EPL chain A against the predicted model O00257: TM-score 0.84, RMSD 2.00 Å
- 2K28 chain A against the predicted model O00257: TM-score 0.73, RMSD 1.56 Å
- 2K28 chain A against the predicted model O00257: TM-score 0.73, RMSD 1.56 Å
- 3I8Z chain A against the predicted model O00257: TM-score 0.70, RMSD 2.36 Å
- 3I8Z chain A against the predicted model O00257: TM-score 0.70, RMSD 2.36 Å
Elsewhere
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