UniProt O00167
Eyes absent homolog 2 (O00167)
Eyes absent homolog 2 (UniProt O00167), EC 3.1.3.48: 8 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 4 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O00167
- Protein
- Eyes absent homolog 2
- EC
- 3.1.3.48
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 4 · 1 record with a druggable one
Structures
9 records of O00167 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3GEB | Crystal Structure of edeya2 | x-ray diffraction | A, B, C, D | — | — |
| 3GEB | Crystal structure of EDEYA2 | x-ray diffraction | A, B, C, D | — | — |
| 4EGC | Crystal Structure of MBP-fused Human Six1 Bound to Human Eya2 Eya Domain | x-ray diffraction | B | — | — |
| 4EGC | Crystal structure of mbp-fused human SIX1 bound to human EYA2 eya domain | x-ray diffraction | B | — | — |
| 5ZMA | Structural basis for an allosteric EYA2 phosphatase inhibitor | x-ray diffraction | B, A, C | 9FX | — |
| 7F8G | Structure-activity relationship studies of allosteric inhibitors of EYA2 tyrosine phosphatase | x-ray diffraction | B, A | 1RI | 4 (best 0.69) |
| 7F8G | Structure-activity relationship studies of allosteric inhibitors of EYA2 tyrosine phosphatase | x-ray diffraction | B, A | 1RI | — |
| 7F8H | Structure-activity relationship studies of allosteric inhibitors of EYA2 tyrosine phosphatase | x-ray diffraction | B, A, C | 1SI | — |
| O00167 | AlphaFold monomer V2.0 prediction for eyes absent homolog 2 (O00167) | predicted | A | — | — |
Ligands
- 1RI · 3-phenoxy-~{N}-[(~{E})-(5-pyrimidin-2-ylsulfanylfuran-2-yl)methylideneamino]benzamide · in 2 records
- 1SI · 3-fluoranyl-~{N}-[(~{E})-(5-pyridin-2-ylsulfanylfuran-2-yl)methylideneamino]benzamide · in 1 record
- 9FX · 3-fluoro-N'-[(E)-{5-[(pyrimidin-2-yl)sulfanyl]furan-2-yl}methylidene]benzohydrazide · in 1 record
Experiment against prediction
- 4EGC chain B against the predicted model O00167: TM-score 0.99, RMSD 0.70 Å
- 4EGC chain B against the predicted model O00167: TM-score 0.99, RMSD 0.70 Å
- 3GEB chain B against the predicted model O00167: TM-score 0.99, RMSD 0.66 Å
- 3GEB chain B against the predicted model O00167: TM-score 0.99, RMSD 0.66 Å
- 3GEB chain D against the predicted model O00167: TM-score 0.99, RMSD 0.67 Å
- 3GEB chain D against the predicted model O00167: TM-score 0.99, RMSD 0.67 Å
- 3GEB chain C against the predicted model O00167: TM-score 0.98, RMSD 1.19 Å
- 3GEB chain C against the predicted model O00167: TM-score 0.98, RMSD 1.19 Å
- 3GEB chain A against the predicted model O00167: TM-score 0.98, RMSD 1.22 Å
- 3GEB chain A against the predicted model O00167: TM-score 0.98, RMSD 1.22 Å
Elsewhere
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