UniProt L8GJB3
sterol 14a-demethylase (L8GJB3)
sterol 14a-demethylase (UniProt L8GJB3), EC 1.14.13.70: 7 experimental structures on GenesisL1, 6 ligands bound, 40 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- L8GJB3
- Protein
- sterol 14a-demethylase
- EC
- 1.14.13.70
- Experimental structures
- 7
- Predicted models
- 0
- Ligands
- 6
- Pockets
- 40 · 2 records with a druggable one
Structures
7 records of L8GJB3 in the MolNFT archive: 7 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6Q2C | Domain-swapped dimer of acanthamoeba castellanii CYP51 | x-ray diffraction | A, B | HEM, K | — |
| 6UW2 | Clotrimazole bound complex of acanthamoeba castellanii CYP51 | x-ray diffraction | A, B, C, D, E, F | HEM, CL6, GAI | — |
| 6UX0 | Isavuconazole bound complex of acanthamoeba castellanii CYP51 | x-ray diffraction | A, B, C, D, E, F | HEM, FE | — |
| 7LES | Acanthamoeba castellanii CYP51 (AcCYP51)-Imidazole complex | x-ray diffraction | A, B, C, D | HEM | 20 (best 0.87) |
| 7LES | Acanthamoeba castellanii CYP51 (ACCYP51)-imidazole complex | x-ray diffraction | A, B, C, D | HEM | — |
| 7UWP | Detergent-bound CYP51 from Acanthamoeba castellanii | x-ray diffraction | A, B | HEM | — |
| 8EKT | CYP51 from Acanthamoeba castellanii in complex with the tetrazole-based IND inhibitor VT-1161(VT1) | x-ray diffraction | A, B, C, D, E, F | HEM, VT1 | 20 (best 0.85) |
Ligands
- HEM · Protoporphyrin IX containing Fe · in 7 records
- CL6 · 1-[(2-chlorophenyl)(diphenyl)methyl]-1H-imidazole · in 1 record
- FE · Fe (III) ion · in 1 record
- GAI · Guanidine · in 1 record
- K · Potassium ion · in 1 record
- VT1 · (R)-2-(2,4-Difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(4-(2,2,2-trifluoroethoxy)phenyl)pyridin-2-yl)propan-2-ol · in 1 record
Elsewhere
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