UniProt H2E7Q8
Prolyl oligopeptidase (H2E7Q8)
Prolyl oligopeptidase (UniProt H2E7Q8): 10 experimental structures and 1 predicted model on GenesisL1, 52 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- H2E7Q8
- Protein
- Prolyl oligopeptidase
- Experimental structures
- 10
- Predicted models
- 1
- Pockets
- 52 · 5 records with a druggable one
Structures
11 records of H2E7Q8 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5N4B | Prolyl oligopeptidase B from Galerina marginata bound to 25mer macrocyclization substrate - S577A… | x-ray diffraction | A, B | — | 13 (best 0.79) |
| 5N4B | Prolyl oligopeptidase B from galerina marginata bound to 25MER macrocyclization substrate - S577A… | x-ray diffraction | A, B | — | — |
| 5N4C | Prolyl oligopeptidase B from Galerina marginata bound to 35mer hydrolysis and macrocyclization… | x-ray diffraction | A, B, C, D | — | — |
| 5N4C | Prolyl oligopeptidase B from galerina marginata bound to 35MER hydrolysis and macrocyclization… | x-ray diffraction | A, B, C, D | — | — |
| 5N4D | Prolyl oligopeptidase B from Galerina marginata bound to 25mer macrocyclization substrate - D661A… | x-ray diffraction | A, B | — | 11 (best 0.83) |
| 5N4D | Prolyl oligopeptidase B from galerina marginata bound to 25MER macrocyclization substrate - D661A… | x-ray diffraction | A, B | — | — |
| 5N4E | Prolyl oligopeptidase B from Galerina marginata bound to 35mer hydrolysis and macrocyclization… | x-ray diffraction | A, B | — | 16 (best 0.85) |
| 5N4E | Prolyl oligopeptidase B from galerina marginata bound to 35MER hydrolysis and macrocyclization… | x-ray diffraction | A, B | — | — |
| 5N4F | Prolyl oligopeptidase B from Galerina marginata - apo protein | x-ray diffraction | A | — | 5 (best 0.70) |
| 5N4F | Prolyl oligopeptidase B from galerina marginata - apo protein | x-ray diffraction | A | — | — |
| H2E7Q8 | AlphaFold monomer V2.0 prediction for dual function macrocyclase- peptidase popb (H2E7Q8) | predicted | A | — | 7 (best 0.72) |
Experiment against prediction
- 5N4E chain A against the predicted model H2E7Q8: TM-score 1.00, RMSD 0.32 Å
- 5N4E chain A against the predicted model H2E7Q8: TM-score 1.00, RMSD 0.32 Å
- 5N4B chain A against the predicted model H2E7Q8: TM-score 1.00, RMSD 0.34 Å
- 5N4B chain A against the predicted model H2E7Q8: TM-score 1.00, RMSD 0.34 Å
- 5N4E chain B against the predicted model H2E7Q8: TM-score 1.00, RMSD 0.36 Å
- 5N4E chain B against the predicted model H2E7Q8: TM-score 1.00, RMSD 0.36 Å
- 5N4C chain B against the predicted model H2E7Q8: TM-score 1.00, RMSD 0.38 Å
- 5N4C chain B against the predicted model H2E7Q8: TM-score 1.00, RMSD 0.38 Å
- 5N4C chain D against the predicted model H2E7Q8: TM-score 1.00, RMSD 0.39 Å
- 5N4C chain D against the predicted model H2E7Q8: TM-score 1.00, RMSD 0.39 Å
Elsewhere
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