UniProt G7CNL4
Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase (G7CNL4)
Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase (UniProt G7CNL4), EC 1.1.1.205: 20 experimental structures on GenesisL1, 12 ligands bound, 8 pockets. Binding sites, pockets, druggability and 3D…
- UniProt
- G7CNL4
- Protein
- Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase
- EC
- 1.1.1.205
- Experimental structures
- 20
- Predicted models
- 0
- Ligands
- 12
- Pockets
- 8 · 6 records with a druggable one
Structures
20 records of G7CNL4 in the MolNFT archive: 20 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5J5R | M. thermoresistible GuaB2 delta-CBS in complex with inhibitor VCC234718 | x-ray diffraction | A | 6G1, IMP | — |
| 5J5R | M. thermoresistible GUAB2 delta-cbs in complex with inhibitor VCC234718 | x-ray diffraction | A | — | — |
| 5OU1 | M. thermoresistible IMPDH in complex with IMP and Compound 1 (7759844) | x-ray diffraction | A | IMP, AUQ | 1 (best 0.74) |
| 5OU1 | M. thermoresistible impdh in complex with imp and compound 1 (7759844) | x-ray diffraction | A | IMP, AUQ | — |
| 5OU2 | M. thermoresistible IMPDH in complex with IMP and Compound 2 (NMR744) | x-ray diffraction | A | IMP, 36Y | 1 (best 0.74) |
| 5OU2 | M. thermoresistible impdh in complex with imp and compound 2 (NMR744) | x-ray diffraction | A | IMP, 36Y | — |
| 5OU3 | M. thermoresistible IMPDH in complex with IMP and Compound 31 (AT080) | x-ray diffraction | A | IMP, AUN | 1 (best 0.73) |
| 5OU3 | M. thermoresistible impdh in complex with imp and compound 31 (AT080) | x-ray diffraction | A | IMP, AUN | — |
| 6D4Q | M. thermoresistible GUAB2 delta-cbs in complex with inhibitor compound 14 (VCC900455) | x-ray diffraction | A | IMP, FWG | — |
| 6D4R | M. thermoresistible GuaB2 delta-CBS in complex with inhibitor Compound 18 (VCC399134) | x-ray diffraction | A | IMP, FWY | 3 (best 0.75) |
| 6D4R | M. thermoresistible GUAB2 delta-cbs in complex with inhibitor compound 18 (VCC399134) | x-ray diffraction | A | IMP, FWY | — |
| 6D4S | M. thermoresistible GuaB2 delta-CBS in complex with inhibitor Compound 37 (VCC670597) | x-ray diffraction | A | IMP, FWV | 1 (best 0.73) |
| 6D4S | M. thermoresistible GUAB2 delta-cbs in complex with inhibitor compound 37 (VCC670597) | x-ray diffraction | A | IMP, FWV | — |
| 6D4T | M. thermoresistible GuaB2 delta-CBS in complex with inhibitor Compound 45 (VCC117054) | x-ray diffraction | A | IMP, FWS | — |
| 6D4T | M. thermoresistible GUAB2 delta-cbs in complex with inhibitor compound 45 (VCC117054) | x-ray diffraction | A | IMP, FWS | — |
| 6D4U | M. thermoresistible GUAB2 delta-cbs in complex with inhibitor compound 27 (VCC663664) | x-ray diffraction | A | IMP, FWP | — |
| 6D4V | M. thermoresistible GuaB2 delta-CBS in complex with inhibitor Compound 22 (VCC061422) | x-ray diffraction | A | IMP, FWM | — |
| 6D4V | M. thermoresistible GUAB2 delta-cbs in complex with inhibitor compound 22 (VCC061422) | x-ray diffraction | A | IMP, FWM | — |
| 6D4W | M. thermoresistible GuaB2 delta-CBS in complex with inhibitor Compound 35 (VCC620637) | x-ray diffraction | A | IMP, FWJ | 1 (best 0.74) |
| 6D4W | M. thermoresistible GUAB2 delta-cbs in complex with inhibitor compound 35 (VCC620637) | x-ray diffraction | A | IMP, FWJ | — |
Ligands
- IMP · Inosinic acid · in 19 records
- 36Y · 4-(4-bromophenyl)-1H-imidazole · in 2 records
- AUN · (2~{S})-~{N}-[5-(4-bromophenyl)-1~{H}-imidazol-2-yl]-2-[4-(1-methylimidazol-4-yl)phenoxy]propanamide · in 2 records
- AUQ · (2~{S})-~{N}-(4-iodophenyl)-2-(4-methoxyphenoxy) propanamide · in 2 records
- FWJ · 2-(4-fluorophenyl)-1-{4-[(isoquinolin-5-yl) sulfonyl]piperazin-1-yl}ethan-1-one · in 2 records
- FWM · 2-cyclohexyl-1-{4-[(isoquinolin-5-yl) sulfonyl]piperazin-1-yl}ethan-1-one · in 2 records
- FWS · (2S)-N-(2H-1,3-benzodioxol-5-yl)-4-[(isoquinolin-5-yl) sulfonyl]-2-methylpiperazine-1-carboxamide · in 2 records
- FWV · N-(2,3-dichlorophenyl)-4-[(isoquinolin-5-yl) sulfonyl]piperazine-1-carboxamide · in 2 records
- FWY · hydroxy(3-{4-[(isoquinolin-5-yl)sulfonyl]piperazine-1-carbonyl}phenyl)oxoammonium · in 2 records
- 6G1 · cyclohexyl{4-[(isoquinolin-5-yl)sulfonyl]piperazin-1-yl}methanone · in 1 record
- FWG · Cycloheptyl{4-[(isoquinolin-5-yl)sulfonyl]piperazin-1-yl}methanone · in 1 record
- FWP · 2-(2,4-dimethoxyphenyl)-1-{4-[(isoquinolin-5-yl) sulfonyl]piperazin-1-yl}ethan-1-one · in 1 record
Elsewhere
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