UniProt G7CBF6
Mycobactin import ATP-binding/permease protein IrtB (G7CBF6)
Mycobactin import ATP-binding/permease protein IrtB (UniProt G7CBF6), EC 7.2.2.-: 9 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 127 pockets. Binding sites, druggability and experiment against…
- UniProt
- G7CBF6
- Protein
- Mycobactin import ATP-binding/permease protein IrtB
- EC
- 7.2.2.-
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 127 · 10 records with a druggable one
Structures
10 records of G7CBF6 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 9FW3 | Cryo-EM structure of IrtAB 2xEQ mutant in outward-occluded state in nanodisc in complex with… | electron microscopy | B | ATP, MG, A1IRY | 11 (best 0.88) |
| 9FXC | Cryo-EM structure of IrtAB in inward-facing state in nanodisc | electron microscopy | B | AGS | 14 (best 0.86) |
| 9G2K | Cryo-EM structure of IrtAB in outward-occluded state in nanodisc in complex with ADP-vanadate | electron microscopy | B | AOV, MG | 12 (best 0.85) |
| 9G2L | Cryo-EM structure of IrtAB in inward-facing state in LMNG | electron microscopy | B | — | 18 (best 0.86) |
| 9G2S | Cryo-EM structure of IrtAB 2xEQ, Q249R_IrtB mutant in LMNG | electron microscopy | B | ATP, MG | 12 (best 0.89) |
| 9G2T | Cryo-EM structure of IrtAB 2xEQ, A256R_IrtB mutant in LMNG | electron microscopy | B | ATP, MG | 16 (best 0.89) |
| 9G2V | Cryo-EM structure of IrtAB in inward-facing state in presence of mycobactin under turnover… | electron microscopy | B | ZN, ADP | 13 (best 0.85) |
| 9G36 | Cryo-EM structure of IrtAB 3xHtoA mutant in inward-facing state in presence of mycobactin under… | electron microscopy | B | ADP | 16 (best 0.84) |
| 9GL3 | Cryo-EM structure of IrtAB 2xEQ, A256R_IrtB mutant in LMNG | electron microscopy | B | ATP | 10 (best 0.88) |
| G7CBF6 | AlphaFold monomer V2.0 prediction for mycobactin import ATP- BINDING/PERMEASE protein irtb (G7CBF6) | predicted | A | — | 5 (best 0.59) |
Ligands
Experiment against prediction
- 9G2S chain B against the predicted model G7CBF6: TM-score 0.92, RMSD 2.55 Å
- 9G2K chain B against the predicted model G7CBF6: TM-score 0.92, RMSD 2.56 Å
- 9FW3 chain B against the predicted model G7CBF6: TM-score 0.92, RMSD 2.57 Å
- 9GL3 chain B against the predicted model G7CBF6: TM-score 0.92, RMSD 2.57 Å
- 9G2T chain B against the predicted model G7CBF6: TM-score 0.91, RMSD 2.74 Å
- 9FXC chain B against the predicted model G7CBF6: TM-score 0.86, RMSD 3.66 Å
- 9G2L chain B against the predicted model G7CBF6: TM-score 0.85, RMSD 4.14 Å
- 9G36 chain B against the predicted model G7CBF6: TM-score 0.85, RMSD 3.94 Å
- 9G2V chain B against the predicted model G7CBF6: TM-score 0.84, RMSD 4.16 Å
Elsewhere
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