UniProt G5EG88

Betaine receptor acr-23,Soluble cytochrome b562 (G5EG88)

Betaine receptor acr-23,Soluble cytochrome b562 (UniProt G5EG88): 3 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 60 pockets. Binding sites, druggability and experiment against prediction (TM-score)…

UniProt: G5EG88
Protein: Betaine receptor acr-23,Soluble cytochrome b562
Experimental structures: 3
Predicted models: 1
Ligands: 3
Pockets: 60 · 3 records with a druggable one

Structures

4 records of G5EG88 in the MolNFT archive: 3 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
8ZFK	Caenorhabditis elegans ACR-23 in betaine and monepantel bound state	electron microscopy	D, A, B, C, E	NAG, A1D8E, BET	20 (best 0.84)
8ZFL	Caenorhabditis elegans ACR-23 in apo state	electron microscopy	A, B, C, D, E	NAG	20 (best 0.82)
8ZFM	Caenorhabditis elegans ACR-23 in betaine bound state	electron microscopy	D, A, B, C, E	NAG, BET	20 (best 0.83)
G5EG88	AlphaFold monomer V2.0 prediction for betaine receptor acr-23 (G5EG88)	predicted	A	—	—

Ligands

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 3 records
BET · Trimethyl glycine · in 2 records
A1D8E · ~{N}-[(2~{S})-2-cyano-1-[5-cyano-2-(trifluoromethyl)phenoxy]propan-2-yl]-4-(trifluoromethylsulfanyl)benzamide · in 1 record

Experiment against prediction

8ZFM chain B against the predicted model G5EG88: TM-score 0.96, RMSD 1.56 Å
8ZFM chain D against the predicted model G5EG88: TM-score 0.96, RMSD 1.56 Å
8ZFM chain C against the predicted model G5EG88: TM-score 0.96, RMSD 1.56 Å
8ZFM chain E against the predicted model G5EG88: TM-score 0.96, RMSD 1.56 Å
8ZFM chain A against the predicted model G5EG88: TM-score 0.96, RMSD 1.57 Å
8ZFK chain C against the predicted model G5EG88: TM-score 0.96, RMSD 1.66 Å
8ZFK chain E against the predicted model G5EG88: TM-score 0.96, RMSD 1.67 Å
8ZFK chain B against the predicted model G5EG88: TM-score 0.96, RMSD 1.67 Å
8ZFK chain A against the predicted model G5EG88: TM-score 0.96, RMSD 1.67 Å
8ZFK chain D against the predicted model G5EG88: TM-score 0.96, RMSD 1.67 Å

Elsewhere

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