UniProt G4N374
Mitogen-activated protein kinase MPS1 (G4N374)
Mitogen-activated protein kinase MPS1 (UniProt G4N374), EC 2.7.11.24: 2 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 10 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- G4N374
- Protein
- Mitogen-activated protein kinase MPS1
- EC
- 2.7.11.24
- Experimental structures
- 2
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 10 · 2 records with a druggable one
Structures
3 records of G4N374 in the MolNFT archive: 2 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5Z33 | Crystal structure of mitogen-activated protein kinase MPS1 in magnaporthe oryzae | x-ray diffraction | A | — | — |
| 8H59 | A fungal MAP kinase in complex with an inhibitor | x-ray diffraction | A | KR9 | 3 (best 0.64) |
| G4N374 | AlphaFold monomer V2.0 prediction for mitogen-activated protein kinase MPS1 (G4N374) | predicted | A | — | 7 (best 0.78) |
Ligands
- KR9 · ~{N}-[(2~{S})-3-(1~{H}-indol-3-yl)-1-(methylamino)-1-oxidanylidene-propan-2-yl]-8-[2-methoxy-5-(trifluoromethyloxy)phenyl]-1,6-naphthyridine-2-carboxamide · in 1 record
Experiment against prediction
- 5Z33 chain A against the predicted model G4N374: TM-score 0.93, RMSD 1.15 Å
- 8H59 chain A against the predicted model G4N374: TM-score 0.93, RMSD 1.18 Å
Elsewhere
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