UniProt G3XDA2
3-oxoacyl-[acyl-carrier-protein] synthase 2 (G3XDA2)
3-oxoacyl-[acyl-carrier-protein] synthase 2 (UniProt G3XDA2), EC 2.3.1.179: 15 experimental structures on GenesisL1, 16 ligands bound, 84 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- G3XDA2
- Protein
- 3-oxoacyl-[acyl-carrier-protein] synthase 2
- EC
- 2.3.1.179
- Experimental structures
- 15
- Predicted models
- 0
- Ligands
- 16
- Pockets
- 84 · 12 records with a druggable one
Structures
15 records of G3XDA2 in the MolNFT archive: 15 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4JPF | Structure of wild type Pseudomonas aeruginosa FabF (KASII) in Complex with ligand | x-ray diffraction | A | — | — |
| 4JPF | Structure of wild type pseudomonas aeruginosa fabf (kasii) in complex with ligand | x-ray diffraction | A | — | — |
| 7OC0 | Structure of pseudomonas aeruginosa fabf mutant C164Q in complex with a ligand… | x-ray diffraction | A, B | V7W, MG | — |
| 8CN2 | Pa.FabF-C164Q in complex with N-isobutyl-1H-pyrazole-3-carboxamide | x-ray diffraction | B, A | V60 | 7 (best 0.79) |
| 8CN4 | Pa.FabF-C164Q in complex with 5-acetamido-2-chlorobenzoic acid | x-ray diffraction | A, B | MG, V5R | 9 (best 0.75) |
| 8CN5 | Pa.FabF-C164Q in complex with propan-2-yl 1~{H}-pyrazole-3-carboxylate | x-ray diffraction | B, A | PO4, V5K | 9 (best 0.74) |
| 8CNE | Pa.FabF-C164A in complex with N-(propan-2-yl)-1H-pyrazole-3-carboxamide | x-ray diffraction | A, B | Q5L, PO4 | 3 (best 0.69) |
| 8CNG | Pa.FabF-C164Q in complex with ~{N}-cyclopentyl-3-methyl-1~{H}-pyrazole-5-carboxamide | x-ray diffraction | A, B | MG, V6L | 8 (best 0.73) |
| 8COU | Pa.FabF-C164Q in complex with 3-acetamido-4-methoxybenzoic acid | x-ray diffraction | A, B | VCZ, PO4 | 7 (best 0.72) |
| 8COV | Pa.FabF-C164Q in complex with 6-chloro-2-methyl-1H-indole-5-carboxylic acid | x-ray diffraction | A, B | VBR, PO4 | 6 (best 0.74) |
| 8PFZ | Pseudomonas aeruginosa FabF C164A mutant in complex with(S)-2-(1H-pyrazole-3-carboxamido)butanoic… | x-ray diffraction | A, B | PO4, YQI, CL | 5 (best 0.69) |
| 8PJ0 | Pseudomonas aeruginosa FabF C164A mutant in complex with… | x-ray diffraction | A, B, C, D | ZHX | 15 (best 0.81) |
| 8QM1 | wild type Pa.FabF in complex cerulenin | x-ray diffraction | A, B | CER, PO4 | 6 (best 0.77) |
| 8R0I | Pseudomonas aeruginosa FabF C164A in complex with 3-amino-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro… | x-ray diffraction | A, B | XG7 | 5 (best 0.71) |
| 8R1V | Pseudomonas aeruginosa FabF C164A in complex with N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyra… | x-ray diffraction | A, B | XJR | 4 (best 0.73) |
Ligands
- PO4 · Phosphate ion · in 6 records
- MG · Magnesium ion · in 3 records
- CER · (2S, 3R)-3-hydroxy-4-oxo-7,10-trans,trans-dodecadienamide · in 1 record
- CL · Chloride ion · in 1 record
- Q5L · N-(propan-2-yl)-1H-pyrazole-3-carboxamide · in 1 record
- V5K · propan-2-yl 1~{H}-pyrazole-3-carboxylate · in 1 record
- V5R · 5-acetamido-2-chloranyl-benzoic acid · in 1 record
- V60 · ~{N}-(2-methylpropyl)-1~{H}-pyrazole-3-carboxamide · in 1 record
- V6L · ~{N}-cyclopentyl-3-methyl-1~{H}-pyrazole-5-carboxamide · in 1 record
- V7W · (2S,4R)-2-(thiophen-2-yl)thiazolidine-4-carboxylic acid · in 1 record
- VBR · 6-chloranyl-2-methyl-1~{H}-indole-5-carboxylic acid · in 1 record
- VCZ · 3-acetamido-4-methoxy-benzoic acid · in 1 record
- XG7 · 3-azanyl-N-(1,5-dimethyl-3-oxidanylidene-2-phenyl-pyrazol-4-yl)benzamide · in 1 record
- XJR · N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-(4-methoxyphenoxy)acetamide · in 1 record
- YQI · (2~{S})-2-(1~{H}-pyrazol-3-ylcarbonylamino)butanoic acid · in 1 record
- ZHX · ~{N}-(1,5-dimethyl-3-oxidanylidene-2-phenyl-pyrazol-4-yl)-3-methyl-butanamide · in 1 record
Elsewhere
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