UniProt G3XCV0
Transcriptional regulator FleQ (G3XCV0)
Transcriptional regulator FleQ (UniProt G3XCV0): 13 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 30 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- G3XCV0
- Protein
- Transcriptional regulator FleQ
- Experimental structures
- 13
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 30 · 3 records with a druggable one
Structures
14 records of G3XCV0 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4WXM | FleQ REC domain from Pseudomonas aeruginosa PAO1 | x-ray diffraction | A, B, C, D, E | — | — |
| 4WXM | Fleq rec domain from pseudomonas aeruginosa PAO1 | x-ray diffraction | A, B, C, D, E | — | — |
| 5EXP | AAA+ domain of FleQ from Pseudomonas aeruginosa | x-ray diffraction | A | SO4 | — |
| 5EXP | Aaa+ domain of fleq from pseudomonas aeruginosa | x-ray diffraction | A | — | — |
| 5EXS | AAA+ ATPase FleQ from Pseudomonas aeruginosa bound to ATP-gamma-S | x-ray diffraction | A | AGS | 1 (best 0.55) |
| 5EXS | Aaa+ ATPase fleq from pseudomonas aeruginosa bound to ATP-gamma-S | x-ray diffraction | A | — | — |
| 5EXT | AAA+ domain of FleQ from Pseudomonas aeruginosa bound to ADP | x-ray diffraction | A | ADP | — |
| 5EXT | Aaa+ domain of fleq from pseudomonas aeruginosa bound to ADP | x-ray diffraction | A | — | — |
| 5EXX | AAA+ ATPase FleQ from Pseudomonas aeruginosa bound to c-di-GMP | x-ray diffraction | A | SO4, C2E | — |
| 5EXX | Aaa+ ATPase fleq from pseudomonas aeruginosa bound to C-di-gmp | x-ray diffraction | A | — | — |
| 7EJW | Crystal structure of flen in complex with fleq aaa+ doamain | x-ray diffraction | C, D | MG | — |
| 8P53 | Cryo-EM structure of the c-di-GMP-free FleQ-FleN master regulator complex of P. aeruginosa | electron microscopy | C, D, E, F | — | 17 (best 0.77) |
| 8PB9 | Cryo-EM structure of the c-di-GMP-bound FleQ-FleN master regulator complex from Pseudomonas… | electron microscopy | D, C, E | C2E | 12 (best 0.85) |
| G3XCV0 | AlphaFold monomer V2.0 prediction for transcriptional regulator fleq (G3XCV0) | predicted | A | — | — |
Ligands
- C2E · 9,9'-[(2r,3r,3as,5s,7ar,9r,10r,10as,12s,14ar)-3,5,10, 12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3, 2-D:3',2'-J][1,3,7,9,2, 8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one) · in 2 records
- SO4 · Sulfate ion · in 2 records
- ADP · Adenosine-5'-diphosphate · in 1 record
- AGS · Phosphothiophosphoric acid-adenylate ester · in 1 record
- MG · Magnesium ion · in 1 record
Experiment against prediction
- 4WXM chain E against the predicted model G3XCV0: TM-score 0.98, RMSD 0.57 Å
- 4WXM chain E against the predicted model G3XCV0: TM-score 0.98, RMSD 0.57 Å
- 7EJW chain C against the predicted model G3XCV0: TM-score 0.98, RMSD 0.92 Å
- 5EXT chain A against the predicted model G3XCV0: TM-score 0.97, RMSD 1.06 Å
- 5EXT chain A against the predicted model G3XCV0: TM-score 0.97, RMSD 1.06 Å
- 4WXM chain B against the predicted model G3XCV0: TM-score 0.97, RMSD 1.02 Å
- 4WXM chain B against the predicted model G3XCV0: TM-score 0.97, RMSD 1.02 Å
- 4WXM chain A against the predicted model G3XCV0: TM-score 0.97, RMSD 0.84 Å
- 4WXM chain A against the predicted model G3XCV0: TM-score 0.97, RMSD 0.84 Å
- 5EXS chain A against the predicted model G3XCV0: TM-score 0.97, RMSD 1.11 Å
Elsewhere
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