UniProt G1T7U7
N-acylethanolamine acid amidase alpha-subunit (G1T7U7)
N-acylethanolamine acid amidase alpha-subunit (UniProt G1T7U7), EC 3.5.1.60: 6 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 9 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- G1T7U7
- Protein
- N-acylethanolamine acid amidase alpha-subunit
- EC
- 3.5.1.60
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 9 · 3 records with a druggable one
Structures
7 records of G1T7U7 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6DXZ | Rabbit N-acylethanolamine-hydrolyzing acid amidase (NAAA) in complex with non-covalent… | x-ray diffraction | A, B | NAG, K, TRT, 27L, WTF, TON | 3 (best 0.83) |
| 6DXZ | Rabbit N-acylethanolamine-hydrolyzing acid amidase (naaa) in complex with non-covalent… | x-ray diffraction | A, B | NAG, K, TRT, 27L, WTF, TON | — |
| 6DY0 | Rabbit N-acylethanolamine-hydrolyzing acid amidase (NAAA) covalently bound to beta-lactam inhibitor… | x-ray diffraction | A, B | NAG, CL, TON, HJA | 2 (best 0.79) |
| 6DY0 | Rabbit N-acylethanolamine-hydrolyzing acid amidase (naaa) covalently bound to beta-lactam inhibitor… | x-ray diffraction | A, B | NAG, CL, TON, HJA | — |
| 6DY1 | Rabbit N-acylethanolamine-hydrolyzing acid amidase (NAAA) with fatty acid (myristate), in presence… | x-ray diffraction | A, B | NAG, SO4, CL, TON, MYR | 4 (best 0.83) |
| 6DY1 | Rabbit N-acylethanolamine-hydrolyzing acid amidase (naaa) with fatty acid (myristate), in presence… | x-ray diffraction | A, B | NAG, SO4, CL, TON, MYR | — |
| G1T7U7 | AlphaFold monomer V2.0 prediction for N-acylethanolamine-hydrolyzing acid amidase (G1T7U7) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 6 records
- TON · 2-{2-[4-(1,1,3,3-tetramethylbutyl) phenoxy]ethoxy}ethanol · in 6 records
- CL · Chloride ion · in 4 records
- 27L · 4-(2,4,4-trimethylpentan-2-yl)phenol · in 2 records
- HJA · (2S)-3-amino-2-{[(4-cyclohexylbutoxy) carbonyl]amino}propanethioic S-acid · in 2 records
- K · Potassium ion · in 2 records
- MYR · Myristic acid · in 2 records
- SO4 · Sulfate ion · in 2 records
- TRT · Fragment of triton X-100 · in 2 records
- WTF · [2-(ethylsulfonyl)phenyl][(2S)-4-(6-fluoro-1,3-benzothiazol-2-yl)-2-methylpiperazin-1-yl]methanone · in 2 records
Experiment against prediction
- 6DXZ chain B against the predicted model G1T7U7: TM-score 0.99, RMSD 0.61 Å
- 6DXZ chain B against the predicted model G1T7U7: TM-score 0.99, RMSD 0.61 Å
- 6DY0 chain B against the predicted model G1T7U7: TM-score 0.98, RMSD 0.84 Å
- 6DY0 chain B against the predicted model G1T7U7: TM-score 0.98, RMSD 0.84 Å
- 6DY1 chain B against the predicted model G1T7U7: TM-score 0.98, RMSD 0.98 Å
- 6DY1 chain B against the predicted model G1T7U7: TM-score 0.98, RMSD 0.98 Å
- 6DY1 chain A against the predicted model G1T7U7: TM-score 0.88, RMSD 1.67 Å
- 6DY1 chain A against the predicted model G1T7U7: TM-score 0.88, RMSD 1.67 Å
- 6DXZ chain A against the predicted model G1T7U7: TM-score 0.88, RMSD 1.65 Å
- 6DXZ chain A against the predicted model G1T7U7: TM-score 0.88, RMSD 1.65 Å
Elsewhere
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