UniProt F4KCC2
E3 ubiquitin-protein ligase PRT6 (F4KCC2)
E3 ubiquitin-protein ligase PRT6 (UniProt F4KCC2), EC 2.3.2.27: 6 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 25 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- F4KCC2
- Protein
- E3 ubiquitin-protein ligase PRT6
- EC
- 2.3.2.27
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 25 · 2 records with a druggable one
Structures
7 records of F4KCC2 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6LHN | Rlgsgg-ATPRT6 ubr box | x-ray diffraction | A | ZN | — |
| 7XWD | Apo-AtPRT6 UBR box | x-ray diffraction | A | ZN | — |
| 7XWE | RRGSGG-AtPRT6 UBR box | x-ray diffraction | A, B | MG, ZN | — |
| 7XWF | RLGSGG-AtPRT6 UBR box (highest resolution) | x-ray diffraction | A | ZN | — |
| 7Y6W | RRGSGG-AtPRT6 UBR box (I222) | x-ray diffraction | A | ZN | — |
| 7Y6X | RRGSGG-AtPRT6 UBR box (P32) | x-ray diffraction | A, B, D, E, F, G, H, C | ZN | 5 (best 0.72) |
| F4KCC2 | AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase PRT6 (F4KCC2) | predicted | A | — | 20 (best 0.79) |
Ligands
Experiment against prediction
- 7XWD chain A against the predicted model F4KCC2: TM-score 0.95, RMSD 0.73 Å
- 7XWF chain A against the predicted model F4KCC2: TM-score 0.93, RMSD 1.37 Å
- 7Y6W chain A against the predicted model F4KCC2: TM-score 0.93, RMSD 1.32 Å
- 7XWE chain A against the predicted model F4KCC2: TM-score 0.89, RMSD 1.14 Å
- 7Y6X chain B against the predicted model F4KCC2: TM-score 0.89, RMSD 0.86 Å
- 6LHN chain A against the predicted model F4KCC2: TM-score 0.89, RMSD 1.05 Å
- 7XWE chain B against the predicted model F4KCC2: TM-score 0.89, RMSD 1.17 Å
- 7Y6X chain G against the predicted model F4KCC2: TM-score 0.88, RMSD 1.27 Å
- 7Y6X chain C against the predicted model F4KCC2: TM-score 0.88, RMSD 1.27 Å
- 7Y6X chain E against the predicted model F4KCC2: TM-score 0.88, RMSD 1.28 Å
Elsewhere
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