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UniProt E1ANT8

Pol protein (E1ANT8)

Pol protein (UniProt E1ANT8): 6 experimental structures on GenesisL1, 5 ligands bound, 40 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.

UniProt
E1ANT8
Protein
Pol protein
Experimental structures
6
Predicted models
0
Ligands
5
Pockets
40 · 2 records with a druggable one

Structures

6 records of E1ANT8 in the MolNFT archive: 6 experimental, 0 predicted.

EntryTitleMethodChainsLigandsPockets
6RWLSivrcm intasomeelectron microscopyA, B, C, D, F, M, I, J, K, L, N, EZN—
6RWMSivrcm intasome in complex with bictegravirelectron microscopyA, B, C, D, F, M, I, J, K, L, N, EZN, MG, KLQ, CL—
6RWNSIVrcm intasome in complex with dolutegravirelectron microscopyA, E, N, L, K, J, I, M, F, D, C, BZN, CL, DLU, MG20 (best 0.84)
6RWNSivrcm intasome in complex with dolutegravirelectron microscopyA, E, N, L, K, J, I, M, F, D, C, BZN, CL, DLU, MG—
6RWOSIVrcm intasome (Q148H/G140S) in complex with bictegravirelectron microscopyA, E, N, L, K, J, I, M, F, D, C, BZN, CL, KLQ, MG20 (best 0.84)
6RWOSivrcm intasome (Q148H/G140S) in complex with bictegravirelectron microscopyA, E, N, L, K, J, I, M, F, D, C, BZN, CL, KLQ, MG—

Ligands

  • ZN · Zinc ion · in 6 records
  • CL · Chloride ion · in 5 records
  • MG · Magnesium ion · in 5 records
  • KLQ · Bictegravir · in 3 records
  • DLU · (4r,12as)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6, 8-dioxo-3,4,6,8,12,12A-hexahydro-2H-pyrido[1',2':4, 5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide · in 2 records

Elsewhere

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