UniProt D6WJ77
Protein-S-isoprenylcysteine O-methyltransferase (D6WJ77)
Protein-S-isoprenylcysteine O-methyltransferase (UniProt D6WJ77), EC 2.1.1.100: 4 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 11 pockets. Binding sites, druggability and experiment against…
- UniProt
- D6WJ77
- Protein
- Protein-S-isoprenylcysteine O-methyltransferase
- EC
- 2.1.1.100
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 11 · 3 records with a druggable one
Structures
5 records of D6WJ77 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5V7P | Atomic structure of the eukaryotic intramembrane Ras methyltransferase ICMT (isoprenylcysteine… | x-ray diffraction | A | SAH, D10, MPG | 3 (best 0.84) |
| 5V7P | Atomic structure of the eukaryotic intramembrane RAS methyltransferase icmt (isoprenylcysteine… | x-ray diffraction | A | D10, MPG | — |
| 5VG9 | Structure of the eukaryotic intramembrane Ras methyltransferase ICMT (isoprenylcysteine carboxyl… | x-ray diffraction | A | SAH | 3 (best 0.79) |
| 5VG9 | Structure of the eukaryotic intramembrane RAS methyltransferase icmt (isoprenylcysteine carboxyl… | x-ray diffraction | A | — | — |
| D6WJ77 | AlphaFold monomer V2.0 prediction for protein-S-isoprenylcysteine O-methyltransferase (D6WJ77) | predicted | A | — | 5 (best 0.76) |
Ligands
Experiment against prediction
- 5VG9 chain A against the predicted model D6WJ77: TM-score 0.99, RMSD 0.64 Å
- 5VG9 chain A against the predicted model D6WJ77: TM-score 0.99, RMSD 0.64 Å
- 5V7P chain A against the predicted model D6WJ77: TM-score 0.99, RMSD 0.80 Å
- 5V7P chain A against the predicted model D6WJ77: TM-score 0.98, RMSD 0.80 Å
Elsewhere
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